Important cytokines Flashcards
IL-1
Secreted By mAcrophAgeS
Also called osteoclast-activating factor
Causes *fever, acute inflammation.
Activates endothelium to express adhesion molecules.
Induces chemokine secretion to recruit *WBCs.
IL-6
Secreted By mAcrophAgeS
Causes fever and stimulates production of *acute phase
proteins
IL-8
Secreted By mAcrophAgeS
Major chemotactic factor for *neutrophils
“Clean up on aisle 8.”
*Neutrophils are recruited
by IL-8 to clear infections.
IL-12
Secreted By mAcrophAgeS
Induces differentiation of T cells into *Th1 cells.
Activates *NK cells
TNF-a
Secreted By mAcrophAgeS
Mediates *septic shock.
Activates endothelium.
Causes WBC recruitment, vascular leak.
Causes *cachexia in malignancy
IL-2
Secreted by ALL T CELLS
Stimulates growth of helper, cytotoxic, and regulatory *T cells, and *NK cells.
IL-3
Secreted by ALL T CELLS
Supports growth and differentiation of *bone marrow stem cells
Functions like GM-CSF.
Interferon-gamma
Secreted by Th1 CELLS
Secreted by *NK cells and *T cells in response to *IL-12 from macrophages
stimulates macrophages to kill phagocytosed pathogens.
Inhibits differentiation of *Th2 cells.
Also activates *NK cells to kill virus-infected cells
Increases MHC expression and antigen presentation by all cells.
IL-4
Secreted from Th2 CELLS
Induces differentiation of T cells into *Th2 cells.
Promotes growth of *B cells
Enhances class switching to *IgE and IgG
IL-5
Secreted from Th2 CELLS
Promotes growth and differentiation of *B cells
Enhances class switching to *IgA
Stimulates growth and differentiation of *eosinophils
IL-10
Attenuates inflammatory response
Decreases expression of MHC class II and *Th1 cytokines
Inhibits activated macrophages and dendritic
cells
Also secreted by *regulatory T cells.
*TGF-β and IL-10 both *attenuate the immune response
