Genetics

Question 1

Oncogenes are

Answer 1

if activated initiate cancer

ex. c-myc = burkitt’s lymphoma

Question 2

C-myc

Answer 2

burkitt’s lymphoma

Question 3

C-abl

Answer 3

CML

Question 4

bcl-2

Answer 4

Non-H lymphoma

Question 5

Ras

Answer 5

colon carcinoma

Question 6

tumor suppressor genes

Answer 6

if turned off promotes cancer, helps to keep mitosis in check

ex. BRCA-1

Question 7

BRCA-1

Answer 7

breast, ovarian

Question 8

BRCA - 2, p53

Answer 8

breast, colon, bronchial carcinoma

Question 9

RB1

Answer 9

retinblastoma

Question 10

Metaplasia stage is

Answer 10

reversible

Question 11

Lung tumors spread to

Answer 11

the brain (50% of brain tumors)

Question 12

Breast tumors spread to

Answer 12

the bone

Question 13

PSA

Answer 13

prostate marker

Question 14

CA-125

Answer 14

ovarian marker

Question 15

hCG

Answer 15

germ cell tumor

Question 16

AFP

Answer 16

normal for liver, or ovarian/reproductive or hepatocellular carcinoma

Question 17

CEA

Answer 17

colorectal, gastric, thyroid, rectal, pancreatic

Question 18

Adeno vs. squamous vs. basal

Answer 18

glandular vs. skin (superficial layer) vs skin

Question 19

X-linked recessive

Answer 19

hemophilia A & B, glucose-6-phosphate def

-men will be sick XY (mother to son), women can be healthy

Question 20

if the disease is present in every generation it is

Answer 20

dominant

Question 21

if the disease skipped a generation it is

Answer 21

recessive

Question 22

if the tranmission is father to son it is

Answer 22

autosomal

Question 23

if they transmission is x-linked it is

Answer 23

x-linked

Question 24

HLA b27

Answer 24

psoriasis, ankylosing spondylitis, IBD, reiter’s syndrome

Question 25

HLA DR2

Answer 25

MS, nacrolepsy

Question 26

HLA DR3

Answer 26

DM1, SLE

Question 27

HLA DR4

Answer 27

RA, DM1

Question 28

HLA DR5

Answer 28

pernicious anemia, Hashimoto’s

Question 29

HLA DQ2/8

Answer 29

Celiac dz

Question 30

HLA A3

Answer 30

hemochromatosis