Epithelial Pathology I

Question 1

What is a benign proliferation of stratified squamous epithelium caused by Human Papillomavirus types 6 and 11?

Answer 1

Squamous Papilloma

Question 2

The ability of virus to overcome body’s defenses and cause disease is called?

Answer 2

Virulence

Question 3

The ability to establish infection from one person to another horizontally

Answer 3

Infectivity

Question 4

What 3 things are on the differential diagnosis list along with Squamous Papilloma?

Answer 4

1-Verruca vulgaris
2-Condyloma acuminatum
3-Verruciform xanthoma

Question 5

What contagious presentation is caused by HPV:2,4,6,40?

Answer 5

Verruca Vulgaris

*Oral lesions are more white colored. Has same differential diagnosis list as Squamous Papilloma

Question 6

AKA Venereal Wart, what STD has the same differential diagnosis as Squamous Papilloma and Verruca Vulgaris?

Answer 6

Condyloma Acuminatum

*average size is 1-1.5 cm (much bigger than other warts)

Question 7

What are the 5 main HPV types that cause Condyloma Acuminatum?

Answer 7

1-6* - most common
2-11* - most common
3-16 – high risk
4-18 – high risk
5-31 – high risk

Question 8

Where are HPV type 16 or HPV-18 at increased risk for malignant transformation to squamous cell carcinoma?

Answer 8

Anogenital area

*Not the case with Oral lesions

Question 9

AKA Heck’s Disease, what is caused by HPV 13 and 32 and appears in childhood?

Answer 9

Multifocal Epithelial Hyperplasia

Question 10

A benign, localized proliferations of respiratory mucosa is called what?

Answer 10

Sinonasal Papillomas

*50% arise from the lateral nasal wall

Question 11

What are the 3 patterns of Sinonasal Papillomas?

Answer 11

1-Fungiform
2-Inverted
3-Cylindrical cell

Question 12

A virally-induced epithelial hyperplasia caused by DNA poxvirus typically in children is called?

Answer 12

Molluscum Contagiosum

Question 13

What do you look for histologically in Molluscum Contagiosum?

Answer 13

Molluscum bodies which are also known as Henderson-Paterson bodies

Question 14

A hyperplastic condition which is largely an oral disease of unknown cause (likely trauma) characterized by lipid-laden histiocytes in the epithelium is called?

Answer 14

Verruciform Xanthoma

*Same differential diagnosis as Squamous papilloma

Question 15

Appearing as “stuck onto” the skin, what condition is common in older people and is a benign proliferation of epidermal basal cells of unknown etiology?

Answer 15

Seborrheic Keratosis

*no malignant potential

Question 16

The form of Seborrheic Keratosis that occurs as multiple 2 mm black papules scattered around the zygomatic and periorbital region is called?

Answer 16

Dermatosis papulosa nigra

*30% of African Americans (Morgan Freeman). No malignant potential

Question 17

Sudden appearance of numerous seborrheic keratoses with pruritus has been associated with internal malignancy and is called?

Answer 17

Leser-Trélat sign

Question 18

Commonly called a freckle, what is a hyperpigmented macule of the skin called?

Answer 18

Ephelis

*More pronounced with sun exposure. Associated with painful childhood sunburns

Question 19

A benign brown macule resulting from chronic UV light damage to the skin on the dorsal surfaces with well-demarcated irregular borders is likely?

Answer 19

Actinic Lentigo

*Related to Sun exposure. No change in color intensity with UV light exposure (unlike Ephelis)

Question 20

A benign cutaneous melanocytic hyperplasia that is indistinguishable from the nonelevated melanocytic nevus is called?

Answer 20

Lentigo Simplex

*smaller than 5 mm with uniform brown color that does not change with sunlight

Question 21

An acquired, symmetrical, hormonally-driven hyperpigmentation of the sun-exposed skin of the face is called?

Answer 21

Melasma

*associated with pregnancy

Question 22

What is the oral counterpart to ephelis called?

Answer 22

Oral melanotic Macule

*Most common site = vermilion zone of the lower lip (LABIAL melanotic Macule)

Question 23

An acquired pigmentation of the oral mucosa likely due to trauma almost exclusively in African Americans on the buccal mucosa that rapidly increases in size is called?

Answer 23

Oral Melanoacanthoma

Question 24

The most commonly recognized nevus that is AKA mole is an increased number of cells (melanocytes) resulting in a mass called what?

Answer 24

Acquired Melanocytic Nevus

Question 25

Though intraoral melanocytic nevi are uncommon, where do they typically appear in the oral cavity?

Answer 25

Palate

Question 26

AKA Birthmark, what feature is similar to an acquired melanocytic nevus though they are usually larger?

Answer 26

Congenital Melanocytic Nevus

*Large type may present with Hypertrichosis (Hairy)

Question 27

A melanocytic nevus with a surrounding pale hypo pigmented border is called?

Answer 27

Halo Nevus

Question 28

A benign proliferation of dermal (or intramucosal) melanocytes that appear blue due to the tyndall effect are called?

Answer 28

Blue Nevus

*Common (1 cm usually on palate) and cellular (usually on buttock) types