Nervous System Flashcards
Failure of posterior vertebral arches to close
Spina bifida
Posterior vertebral arch defect most often limited to one or two vertebrae
Spina bifida occulta
No clinically apparent abnormalities
Posterior vertebral arches defect complicated by herniation of meninges through the defect
Spina bifida cystica
Hydrocephalus that occurs without obstruction or increased CSF production in disorders characterized by decreased cerebral mass, such as ischemic brain atrophy or advanced Alzheimer disease.
hydrocephalus ex vacuo
The increased volume of CSF is entirely within the ventricles
Internal hydrocephalus
The increased volume of CSF is confined to the subarachnoid space
External hydrocephalus
This is a downward displacement of the cerebellar tonsils and medulla through the foramen magnum.
Arnold-Chiari malformation
Neural tube defect that is almost always a characteristic of Arnold-Chiari malformation
Thoracolumbar meningomyelocele
Characteristics include facial abnormalities and developmental defects such as microcephaly, atrial septal defect, mental and growth retardation, and other anomalies.
Fetal alcohol syndrome
This autosomal dominant disorder includes nodular proliferations of multinucleated atypical astrocytes forming tubers (small white nodules scattered in the cerebral cortex and periventricular areas), adenoma sebaceum of the skin, and angiomyolipoma of thekidney.
Tuberous sclerosis syndrome
The most frequent sites of thrombotic occlusion in stroke
carotid bifurcation and the middle cerebral artery
The most frequent site of embolic occlusion in stroke
middle cerebral artery
Infarction caused by an obstruction of small vessels in the brain
lacunar strokes
Pure motor lacunar stroke most often results from lesions affecting the
internal capsule
Pure sensory lacunar stroke most often results from lesions affecting the
thalamus
Most common cause of intracerebral hemorrhage
Hypertension
Minute dilations at small artery bifurcations associated with hypertension and may be sites of hemorrhagic rupture in the brain
Charcot-Bouchard aneurysms
Most common site of intracerebral hemorrhage
Basal ganglia and thalamus
Hematoma due to arterial hemorrhage in the head
Epidural hematoma
Due to trauma
Epidural hematoma is caused by bleeding in
Middle meningeal artery
Clinical characteristics include a short period of consciousness (lucid interval), followed by rapidly developing signs of cerebral compression.
Epidural hematoma
The cause is venous bleeding, most often from bridging veins joining the cerebrum to venous sinuses within the dura.
Subdural hematoma
Gradual signs of cerebral compression
Osmotic imbibing of water resulting to slowly enlarging tumorlike mass
Most common portal of entry of infection in CNS
Hematogenous
No lymphatics enter the CNS
In neonates and infants, pyogenic meningitis is most frequently caused by what 3 organisms?
group Bstreptococci, Escherichia coli and Listeria
In older infants, children, and young adults, the pyogenic meningitis is most frequently caused by what 2 organisms?
Streptococcus pneumoniae (pneumococcus) and Neisseria meningitidis
Hemorrhagic destruction of the adrenal cortex, acute hypocorticism with circulatory collapse, and disseminated intravascular coagulation.
Waterhouse-Friderichsen syndrome
Most common cause of cerebral abscess
Middle ear
The most common agent of severe viral encephalitis.
herpes simplex virus
Viral infection characterized by degeneration and necrosis of anterior horn cells of the spinal cord.
Poliomyelitis
Location of negri bodies in rabies
Hippocampus and purkinje cells of the cerebellum
Giant cells with eosinophilic inclusions involving both the nucleus and cytoplasm are characteristics of what viral infection?
CMV
Vehicles for HIV entry into the nervous system and may serve as the viral reservoir.
Monocyte-macrophage
Most common CNS manifestation of HIV
AIDS dementia complex
Direct effect of HIV
Cause of spongiform encephalopathy
Prion disease