Anti-Inflammatory Agents

Question 1

What is the most common anti-inflammatory agent?

Answer 1

Ibuprofen

Question 2

What disease is caused by giving children aspirin?

Answer 2

Reye’s Syndrome

Question 3

What is the maximum amount of Tylenol for adults?

Answer 3

4 grams

Question 4

Who is sensitive/susceptible to adverse effects from anti-inflammatory agents?

Answer 4

African Americans

Question 5

These drugs block or alter the chemical reactions associated with the inflammatory response

Answer 5

Corticosteroids

Question 6

What are some OTC anti-inflammatory agents?

Answer 6

Aspirin, Aleve, Acetaminophen

Question 7

What is a common salicylate?

Answer 7

Aspirin

Question 8

What does aspirin do?

Answer 8

Blocks prostaglandin response, reduces fever, contributes to pain

Question 9

If a patient is receiving 1 aspirin per day, what could this mean?

Answer 9

The patient is receiving the drug to block platelets and prevent clotting

Question 10

Pharmacokinetics of Salicylates

Answer 10

Absorbed in the stomach, metabolized in the liver, excreted in the urine

Question 11

This drug can reduce MI’s and strokes

Answer 11

Aspirin

Question 12

What do NSAIDs do?

Answer 12

Provide strong anti-inflammatory and analgesic effects

Question 13

What is the NSAIDs prototype?

Answer 13

Ibuprofen

Question 14

Loop diuretics, lithium toxicity, and anti hypertensive drug therapy will result from drug-drug interactions with?

Answer 14

NSAIDs

Question 15

COX-1 is found where?

Answer 15

In our bodies

Question 16

What kind of effect does COX-1 have?

Answer 16

General effect

Question 17

This only works at the site of injury

Answer 17

COX-2

Question 18

What is acetylcysteine used for?

Answer 18

Acetaminophen overdose

Question 19

Which drugs will cause a drug-drug interaction with acetaminophen?

Answer 19

Oral anticoagulants and Coumadin

Question 20

When are NSAIDs contraindicated?

Answer 20

Allergy to Sulfonamides

Question 21

What is the prototype for disease modifying anti-rheumatic drugs?

Answer 21

Etanercept (Enbrel)

Question 22

What are DMARDs used to treat?

Answer 22

Arthritis

Question 23

Where is Enbrel derived from?

Answer 23

From Chinese hamster ovary cells

Question 24

Anakinra will cause a drug-drug interaction with what?

Answer 24

Etanercept