Blood Transfusion Proteins

Question 2

Pathogenesis of Allergic Reaction

Answer 2

Type I hypersensitivity against plasma proteins in transfused blood

Question 3

Clinical Presentation of Allergic Reaction

Answer 3

Urticaria, pruritis, wheezing, fever

Question 4

Treatment for Allergic Reaction

Answer 4

Antihistamines

Question 5

Pathogenesis of Anaphylactic Reaction

Answer 5

Severe; IgA deficient individuals must receive blood products that lack IgA

Question 6

Clinical Presentation of Anaphylactic Reaction

Answer 6

Dyspnea, bronchospasm, hypotension, respiratory arrest, shock

Question 7

Pathogenesis of Febrile Nonhemolytic Transfusion Reaction (FNHTR)

Answer 7

Type II hypersensitivity; host Ab against donor HLA Ag and leukocytes

Question 8

Clinical Presentation of Febrile Nonhemolytic Transfusion Reaction (FNHTR)

Answer 8

Fever, headache, chills, flushing

Question 9

Pathogenesis of Acute Hemolytic Transfusion Reaction (HTR)

Answer 9

Type II hypersensitivity reaction; intravascular hemolysis (ABO incompatibility) or extravascular hemolysis (host Ab reaction against foreign Ag on donor RBCs)

Question 10

Clinical Presentation of Acute Hemolytic Transfusion Reaction (HTR)

Answer 10

Fever, hypotension, tachypnea, tachycardia, flank pain, hemoglobinemia (intravascular), jaundice (extravascular hemolysis)

Question 11

Type I hypersensitivity

Answer 11

Allergic reaction

Question 12

Type II hypersensitivity

Answer 12

Febrile Nonhemolytic Transfusion Reaction (FNHTR), Acute Hemolytic Transfusion Reaction (HTR)