Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK > Spondyloarthropathies > Flashcards

Spondyloarthropathies Flashcards

1
Q

What is spondyloarthorpathy?

A

family of inflam arthritides characterized by invovlement of both the spone and joints principally in geneticall predisposed individuals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the main gene associated the spondylarthropathies?

A

HLA-B27

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What diseases is HLA-B27 associated with?

A

ank. spon; reactive arthritis, Crohn’s, uveitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What diseases make p the spondyloarthropathies?

A

ankylosing spondylitis; psoriatic arthritis; reactive arthritis; enteropathic arthirits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are hte differences betweeen mechanical and inflammatory back pain?

A

mechanical- worsened by actvity, typically worst at end of the day, better with rest
inflam-worse with rest, better with activity, signif early morning sitfness (>30 mins)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the shared rheumatological features of the spondyloarthropathies?

A

sacoriliac and spinal involvemtn; enthesitis; dactylitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is dactylitis?

A

“sausage digits”- inflam of entire digit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the extra-articular features seen in the spondyloarthropathies?

A

ocular inflammation (uveitis; conjunctivites; mucocutaneous lesions; aortic incompetence or heart blcok

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is ankylosing spondylitis

A

chronic systemic inflam disorder that primarly affects the spine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the hallmark features of ank spon?

A

sacroiliac joint involvemnt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Who is ank. spon seen in?

A

late adolescence or early adulthood; M:F- 3-5:1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the features of ank. spon in the classificitation?

A 
inflam back pain for longer than 3 months
arthritis
enthesitis (heel)
uveitis
dactylitis
psoriasis
Crohn's
good response to NSAIDs
FHx 
HLA-B27 
inc. CRP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the CVS; resp and neurological involvement seen with ank. spon?

A

aortic valve/ root-aortic regurg
fibrosis of upper lung lobes
A-A subluxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the 7 As for ank. spon??

A 
axial arthritis
anterior uveitis
aortic regurg
apical fibrosis
amyloidosis/Ig A nephropathy
achilles tendinitis
plAntar fasciitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What happens to the spine in pts with ank. spon?

A

syndesmophytes- fusion of vertebrae; question mark posture- straightening of the lordosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What examinations can be done in pts with ank. spon?

A

tragus/occiput to wall- wont be able to
chest expansion- costovertebral joints can be affected
modified schober test- should be >5cm when bend over

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is seen on MRI in ank. spon?

A 
bone density is normal in early disease but reuced in late disease
shiny corners
flowing syndesmophytes
fusion (bamboo spine)
bone marrow oedema
enthesitis
18
Q

What is the treatment for ank. spon?

A

PT; OT; NSAIDs; DMARDS; anti-TNFs

19
Q

What is the newest licensed drug for AS?

A

secukinumab- anti-IL17

20
Q

What is psoriatic arthritis?

A

inflammatory arthritis assoc with psoriasis

21
Q

How is psoriatic arthritis differentiated from RA?

A

no rheumatoid nodules; RF negative

22
Q

What are the clinical features of psoriatic arthritis?

A

sacroilitis; nail involvement; dactylitis; enthesitis; extra-articular features eg eye disease

23
Q

What is seen on x-ray in psoriatic arthritis?

A

marginal erosions and whiskering; pencil in cup deformity; osteolysis; enthesitis

24
Q

Are inflam markers raised with psoriatic arthritis?

A

yes

25
Q

What is the treatment for psoraitic arthritis?

A

PT;OT; NSAIDs; CS; DMARDs; anti-TNFs; anti-IL17

26
Q

What is reactive arthritis?

A

infection induced systemic illness characterized primarly by an inflam synovitis from which viable microbes cannot be cultures

27
Q

What infections tend to induce reactive arthritis?

A

GU- chlaymydia and GI- eg salmonella; shigella

28
Q

Who gets reactive arthritis?

A

young adults (20-40); theres an equal sex distributiona

29
Q

When do reactive arthritis symptoms start after an infeciton?

A

1-4 weeks post infection

30
Q

What is reiters syndrome?

A

a form of reactive arthritis

triad of urethritis; eye inflam; arthritis

31
Q

What are the clinical features of reactive arthritis?

A 
general- fever fatigue; malaise
asymmetrical monoarthritis or oligoarthritis 
enthesitis
mucocutanoues lesions
ocular lesions
mild renal disease
carditis
32
Q

Why does joint fliud analysis need to be done in reactive arthritis?

A

to rule out infection

33
Q

What is the prognosis for reactive arthritis?

A

spontaneously resolve within 6 months

34
Q

What are the treaments for reactive arthritis?

A

NSAIDs; CS; antibiotics for underling infection; PT; OT

35
Q

What treatment is given for resistant/chronic reactive arthritis?

A

DMARDs

36
Q

What is enteropathic arthritis associated with?

A

inflammatory bowel disease

37
Q

where do pts with enteropathic arthritis present with symptoms?

A

several joints, esp knees, ankles, elbows and wrists and sometimes in spine (20% of Crohns pts have sacroilitis) hip or shoulders

38
Q

What are the clinical symptoms associated with enteropathic arthritis?

A

GI-loose, watery stool with mucous and blood
weight loos, low grade fever; eve involvemnet, skin involvement (pyoderma gangrenosum)
enthesitis
oral-apthous ulcers

39
Q

What are the investigatsion done in enteropathic arthritis?

A

upper and lower GI endoscopy; joint aspirate- no organism or crystals; raised inflam markers

40
Q

How does the IBD disease progression correlate with the arthrtisi?

A

arthritis worsens when IBD worsens

41
Q

What is the treatmnet for enteropathic arthritis?

A

treat IBD controls the arthritis; normal analgesia eg paracetamol; steroids; DMARDs

42
Q

Why are NSAIDs not a good idea in enteropathic arthritis?

A

may exacerbate inflam bowel disease

MSK (39 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions