Bone Histology Flashcards

1
Q

What is the precursor to osteoblasts?

A

Mesenechymal stem cells

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2
Q

What is the precursor to osteoclasts?

A

Monocytes

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3
Q

What are the five functions of bone?

A

Protection, support, mechanical basis for movement, storage, blood cell formation (hematopoiesis)

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4
Q

What are the five classifications of bone according to shape?

A

Long, short, irregular, flat, sesamoid

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5
Q

What are the two gross types of bone?

A

Compact and spongy

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6
Q

What are the ends of bones called?

A

Epiphysis

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7
Q

What is the proper name for a bone growth plate?

A

Epiphyseal plate

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8
Q

What is the shaft of a bone called?

A

Diaphysis

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9
Q

What are the four cells of bone?

A

Osteogenic cells, osteoblasts, osteoclasts, and osteocytes

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10
Q

What are the two layers of bone ECM?

A

Osteoid (organic) and inorganic

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11
Q

What is the osteoid layer of bone ECM made up of?

A

Type I collagen and bone matrix proteins (BMPs)

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12
Q

What do bone matrix proteins include?

A

BMPs include GAGs (ex. hyaluronic acid and chondroitin sulfate), glycoproteins, osteocalsin, and osteonectin

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13
Q

What does the inorganic layer of bone ECM made up of?

A

Hydroxyapatite crystals [Ca10(P04)6(OH)2]

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14
Q

Osteogenic cells lead to what?

A

Osteoblasts then osteocytes

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15
Q

What does an osteogenic cell do?

A

Develop into osteoblasts

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16
Q

What does an osteoblast do?

A

Forms bone matrix

17
Q

What does an osteocyte do?

A

Maintains bone tissue

18
Q

What does an osteoclast do?

A

Functions in resorption, the breakdown of bone matrix

19
Q

What are the canals that connect osteocytes?

A

Canaliculi

20
Q

What are the two histologic kinds of bone?

A

Primary (woven) and secondary bone (lamellar)

21
Q

What are the three different kinds of lamellae?

A

Outer circumferential, inner circumferential, and interstitial

22
Q

What are the blood connections between haversian canals?

A

Volkmann’s canal

23
Q

What is the outer most layer of a haversian canal?

A

The cement line

24
Q

What is spongy bone missing that compact bone has?

A

Osteons

25
Q

The trabeculae of spongy bone surrounds what?

A

Red marrow space