Bone Flashcards

1
Q

Functions of Bone?

A

Weight bearing, support, protection and storage of minerals for blood formation.

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2
Q

What are the circular structures in compact bone called?

A

Osteones/Haversian systems

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3
Q

Central canal of compact bone name?

A

Haversian Canal

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4
Q

Horizontal perforating canal of compact bones name?

A

Volkmann’s canal

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5
Q

What is placed around the haversian canal in compact bone?

A

Osteocytes and concentric rings of bone matrix (lamellaes)

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6
Q

Is spongy bone less or more dense than compact bone?

A

Less

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7
Q

Does spongy bone have haversion systems? If No what does it have?

A

No - has a network of lamellated trabeculae filled with bone marrow

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8
Q

What does the orientation of the trabeculae in spongy bone show?

A

Direction of mechanical force

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9
Q

Two types of bone formation?

A

Endochondral (long bones) and Intramembranous (flat bones, mandibles, maxilla, clavilcles)

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10
Q

How is endochondral ossification done?

A

Bone forms as a cartilage model Blood vessels invade the cartilage structure Cartilage replaced with bone, and cartilage kept in epiphyseal growth plate Growth plate eventually ossifies

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11
Q

How is intramembranous ossification done?

A

No cartilage phase

Mesenchymal cells develop into Osteoprogenitor cells that mature into osteoblasts that start depositing bone

Residual mesenchymal cells develop blood vessels and bone marrow

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12
Q

What 3 cells make up bones?

A

Osteoblasts Osteoclasts Osteocytes

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13
Q

What does the mineral hydroxyapatite do in bone?

A

Makes bones stiff and able to support structures and has a high strength under compression

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14
Q

What does collagen do in bone?

A

Gives bone some flexibility reducing risk of fracture High strength under tension

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15
Q

What do osteoblasts do?

A

Produce bone matrix, once surrounded by matrix becomes an osteocyte

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16
Q

What do osteocytes do?

A

Just mature bone, function not well understood

17
Q

What do osteoclasts do?

A

Reabsorb bone matrix

18
Q

What causes osteoporosis?

A

Re-absoprtion is greater than bone formation

19
Q

What causes pagents disease?

A

When re-absorption and formation both are running at high rates

20
Q

What causes osteopetrosis?

A

When reabosption is too low

21
Q

What controls bone mass?

A

Genes and enviroment

22
Q

Do mechanical loads regulate bone mass?

A

Yes