Drugs - Parkinsons - MAOB Inhibitors

Question 1

Which are the MAO-B inhibitors used in Parkinson’s?

Answer 1

Selegiline/Deprenyl (Eldepryl)

Rasagiline (Azilect)

Question 2

What is the method of action of the MAO-B inhibitors used in Parkinson’s?

Answer 2

At a low dose of under 10 mg per day they selectively block dopamine degradation by MAO-B

Question 3

What are the MAO-B drugs metabolized into?

Answer 3

Amphetamine and methamphetamine

Question 4

At what time of the day should you take MAO-B inhibitors?

Answer 4

Before 2 PM because they are metabolized into amphetamine and methamphetamine

Question 5

How long are the MAO-B inhibitors effective for?

Answer 5

Only a short period of time when given as monotherapy so usually they are used as an adjunct to levodopa

Question 6

Which class of drugs used for Parkinson’s may be neuroprotective because they decrease free radical formation arising from dopamine metabolism by MAO?

Answer 6

MAO-B inhibitors

Question 7

What is Zeplar?

Answer 7

An orally disintegrating tablet form of selegiline which avoids first pass metabolism to amphetamine and MAO-A inactivation

Question 8

What is the advantage of Rasagiline over Selegiline?

Answer 8

It is five times more potent at inhibiting MAO-B and it is not metabolized to amphetamine -like substances as selegiline is so it has less psychic stimulation or insomnia