Drugs - Antipsychotic - Atypical 01

Question 1

Which are the atypical antipsychotics?

Answer 1

• Clozapine (Clozaril)
• Risperidone (Risperdal)
• Paliperidone (Invega)
• Olanzapine (Zyprexa)
• Quetiapine (Seroquel)
• Ziprasidone (Geodon)
• Aripiprazole (Abilify)

Question 2

What do all atypical antipsychotics block?

Answer 2

Both D2 and 5HT2A receptors

Question 3

Which is the most anticholinergic antipsychotic?

Answer 3

Clozapine

Question 4

Which atypical antipsychotic has considerable orthostasis due to potent alpha-1 blockade?

Answer 4

Clozapine

Question 5

Which atypical antipsychotics produce weight gain due to H1 and 5HT2C blockade?

Answer 5

Clozapine and Olanzapine

Question 6

Which atypical antipsychotic is the worst for causing dose-related seizures because it lowers the seizure threshold more than any other antipsychotic agent?

Answer 6

Clozapine

Question 7

Which atypical antipsychotic causes agranulocytosis (cannot make white blood cells which can be potentially fatal and you need weekly bloodwork)?

Answer 7

Clozapine

Question 8

What are the side effects of clozapine?

Answer 8

• Agranulocytosis
• high degree of sedation (H1, muscarinic blockade)
• Sialorrhea (M4 agonist)
• high incidence of hyperglycemia (like olanzepine)
• blackbox warning for myocarditis

Question 9

Which is the most effective agent for treatment resistant schizophrenia?

Answer 9

Clozapine