Autonomic Drugs Flashcards
Bethanechol - Action
activates Bowel & Bladder smooth muscle
- resistant to AChE
“Beth activates her Bowel & Bladder”
Bethanechol - Clinical uses?
- Postoperative Ileus
- Neurogenic Ileus
- Urinary retention
Carbachol - Clinical uses?
- Glaucoma
- Pupillary contraction
- Relief of intra-ocular pressure
Carbachol - action?
“Carbon copy of Acetylcholine”
Pilocarpine - Clinical uses?
- Potent stimulator of sweat, tears, & saliva
- Open-angle & Closed-angle Glaucoma
Pilocarpine - actions?
Contracts ciliary muscle of eye (open-angle glaucoma), pupillary sphincter (closed-angle glaucoma)
- resistant to AChE
“You cry, sweat, & drool on your PILOw”
Methacholine - Clinical uses?
Challenge test for diagnosis of asthma
Methacholine - actions?
Stimulates muscarinic receptors in airway when inhaled
Neostigmine - Clinical uses?
- Postoperative & Neurogenic Ileus
- Urinary retention
- Myasthenia gravis
- Reversal of neuromuscular junction blockade (postoperative)
Neostigmine - actions?
- Anti-AChE
- ↑ endogenous ACh
“Neo CNS = No CNS penetration”
Pyridostigmine - Clinical uses?
Myasthenia gravis (long-acting) - does not penetrate CNS
Pyridostigmine - actions?
- Anti-AChE
- ↑ endogenous ACh
- ↑ strength
“pyRIDostigmine gets RID of myasthenia gravis)
Edrophonium - Clinical uses?
Diagnosis of myasthenia gravis (extremely short-acting)
Edrophonium - actions?
- Anti-AChE
- ↑ endogenous ACh
Physostigmine - Clinical uses?
Anticholinergic toxicity
crosses blood-brain barrier → CNS
