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Principles of Disease BJ > Inflammatory Mediators: > Flashcards

Inflammatory Mediators: Flashcards

1
Q

What is arachadonic acid derived from?

A

Omega-6 fatty acids

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2
Q

What is a metabolite of arachadonic acid?

A

Prostoglandins

Leukotriene

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3
Q

Where is leukotriene made?

A

Leukocytes

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4
Q

What do prostoglandins do?

A

Increased blood flow
Some promote platelet aggregation & vasoconscrition
Chemotaxis

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5
Q

What does leukotriene do?

A

Increa permeability & constrict smooth muscle

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6
Q

Another name for serotonin?

A

5-Hydroxytryptamine

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7
Q

Where is serotonin made?

A

PLatelets during degranulation

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8
Q

What does serotonin do?

A

Causes Vasoconstriction

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9
Q

What makes histamine?

A

Platelets
MAst cells
Basophils

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10
Q

What does histamine do?

A

Causes Vasodilation & increased vascular permeability

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11
Q

What receptors does histamine work on>

A

H1 on endothelium

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12
Q

B cells do in inflammation?

A

MEmory B cells
Antibody production
Antigen Presenting

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13
Q

Whats the aciton of macrophages in inflammation?

A

Antigen Presenting
Debris REmoval
Produces interferon (antiviral)

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14
Q

Whats do T cells do in inflammation?

A
  • Produce cytokines to regulate inflammation
  • Lyse cells themselves
  • Produce interferon (antiviral)
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15
Q

What do NK cells do in inflammation:

A

What they always do, fuck shit up.

Destroy foreign cells with granules.

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16
Q

What does ICAM-1 do?

A

Adheres neutorphils to the endothelial surface

17
Q

Wjat does P-selectin do?

A

Interacts with Neutrophil surafces on the endothelium

18
Q

What is SVR?

A

Index of arteriolar constriciton throughout the body

19
Q

What kind of hypersensitivity cusses granulomas?

A

Type 4

20
Q

What are foriegn body type giant cells associated wih?

A

Pyogenic granuloma & implants

21
Q

How to recognise foreign body type giant cells?

A

CEntral overlapping nuclei`

22
Q

Diapedesis?

A

Movement of blood cells out of capillaries

23
Q

What vessel changes cause the triple response?

A

FLush - TRanisent arteriolar constriction
Flare - Local arteriolar dilation
Wheal - Smooth muscle relaxation

Principles of Disease BJ (47 decks)

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