Drug effect on animals Flashcards
1
Q
Effective dose
A
the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it
2
Q
Lethal dose
A
the size dose that will cause death
3
Q
Therapeutic window
A
plasma concentration range of a substance, where it evokes the therapeutic effect without harmful side effects
4
Q
Therapeutic index
A
a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity
5
Q
Developing a human medicine (5 steps)
A
1) discovery 2) preclinical tests 3) clinical tests 4) registering/licensing of the medicament 5) phase IV and post-marketing
6
Q
3R principle
A
replacement, reduction, refinement
