Tumor Drugs

Question 1

Bevacizumab blocks VEGF. AEs?

Answer 1

• bleeding or GI perforation
• HTN
• hypersensitivity

Question 2

Cetuximab blocks EGFR. AEs?

Answer 2

• cardiac or respiratory arrest and/or sudden death
• acneiform rash

Question 3

Erlotinib is a EGFR- TKI. AEs?

Answer 3

-GI (N/V, diarrhea)

bleeding

elevated LFTs

• interstitial lung disease
• ocular

Question 4

Take Glutamic acid orally before meals

Question 5

Imatinib is an oral TKI used for tx following resection of KIT + GIST. AEs?

Answer 5

• GI (dyspepsia, pain, bloating, N/V)
• CHF
• neurologic toxicity
• fluid retention and edema

Question 6

AEs of Leucovorin?

Answer 6

diarrhea and dehydration

Question 7

Methylsergied is a serotonin inhibitor in the Gi. other uses?

Answer 7

vasoconstriction of aa.

migraine therapy

Question 8

What are the actions of octreotide in the GI?

Answer 8

• reduces duodenal HCO3-, amylase, and gastric acidity
• inhibits gallbladder contraction and bile secretion
• inhibits meal-induces increased in SMA and poral vein blood flow

Question 9

AEs of octreotide/

Answer 9

monitor blood glucose

-diarrhea

Question 10

Sorafenib is an oral multi-kinase inhibitor targeting serine/threonine and receptor tyrosine kinases in both tumor and vasculature. What are the targets?

Answer 10

• Raf
• VEGF
• PDGFR-B
• KIT

RET

Question 11

AEs of sorafenib?

Answer 11

-hand-foot rxn charcterized by redness, pain, and swelling on the palms of the hand

Question 12

AEs of Sunitinib?

Answer 12

• thrombocytopenia and bleeding
• QT prolongation
• GI perforation

Question 13

AEs of Trastuzumab?

Answer 13

• LVEF dysfunction and cardiomyopathy
• ISR
• angioedema
• pulmonary toxicity in those with ling disease