Ketamine

Question 1

Ketamine (Class)

Answer 1

non-barbituate/analgesic

Question 2

Ketamine (MOA 3)

Answer 2

rapid acting analgesic characterized by profound analgesia and amnesia

reatins normal protective airway reflexes & spontaneous respirations

stimulates beta 2 adrenergic receptors causing bronchodilation

Question 3

Ketamine (indications 3)

Answer 3

pre-induction agent for RSI

conscious sedation

general analgesia

Question 4

Ketamine (dosage/route)

Answer 4

for RSI: 2mg/kg IV/IO

for sedation/analgesia: 1mg/kg IV/IO over 30-60 sec

4-5mg/kg IM. may repeat with 2-5mg/kg in 5-10 minutes

Question 5

Ketamine (side effects 6)

Answer 5

transient laryngospasm

hypertension

increased cardiac output & myocardial O2 consumption

may increase ICP and CPP

disassociative anesthesia/hallucinations

nausea/vomiting

Question 6

Ketamine (contraindications 6)

Answer 6

known hypersensitivity

known pregnancy

coronary artery disease

infants under 3 mos

glaucoma or acute globe injury

known or suspected schizophrenia

Question 7

Ketamine (special information 3)

Answer 7

requires midazolam after intubation

administration of antiemetic may reduce incidence of vomiting

monitor patient closely for laryngospasm or apnea

Question 8

Ketamine (pediatric note)

Answer 8

refer to pediatric drug guide