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Systemic Disease > 03. Derm II > Flashcards

03. Derm II Flashcards

1
Q

What is the typical presentation of Psoriasis?

A

Well demarcated salmon-pink plaques with silver scales on skin

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2
Q

Psoriasis is associated with which gene?

A

HLA B27

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3
Q

What is Auspitz sign, and in which condition is it found?

A

Pinpoint bleeding when scales are removed

Psoriasis

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4
Q

Psoriasis my be initiated or exacerbated by what type of glaucoma meds?

A

Beta-blockers

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5
Q

What are the “important” treatments for psoriasis?

A 
PUVA
Oral methotraxate
Cyclosporine
Anthralin
Topical Cortico-steroids
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6
Q

What are the “important” ocular findings associated with psoriasis?

A 
Symblepharon
KCS
Dellen
Fliamentary keratitis
Secondary cataract (Tx)
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7
Q

Psoriaritis arthritis is sero-negative/positive?

A

Sero-negative

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8
Q

Psoriaritic arthritis is found in increased prevalence with what genes?

A

HLA B27

HLA B17

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9
Q

Psoriaritic arthritis is associated with what ocular condition?

A

Uveitis

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10
Q

Rosacea is characterized by what signs?

A

Telangiectasia
Erythema
Papules
Pustules

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11
Q

What tissue hypertrophy is commonly found in rosacea?

A

Rhinophyma

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12
Q

What are the common ocular findings of rosacea?

A 
Dry eye
Blepharitis
Phlyctenules
Pannus
Iritis
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13
Q

In ocular rosacea, what causes phlyctenules or perilimbal infiltrates?

A

Staph hypersensitivity

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14
Q

What are the common Txs for rosacea?

A

Tetracycline
Doxycycline
Erythromycin

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15
Q

What Tx is contraindicated in rosacea?

A

Topical fluorinated corticosteroids

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16
Q

Of the three albinism syndromes, in which is bleeding/hemorrhage typically seen?

A

Hermansky-Pudlak

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17
Q

Of the three albinism syndromes, in which is immune dysfunction found?

A

Chediak-Higashi

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18
Q

Which of the three albinism syndromes may display immuno-deficiency?

A

Griscelli

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19
Q

What are the ocular findings in albinism?

A 
Iris TID
Photophobia
Nystagmus
Disposition to RD
Papilledema and infiltration with leukocytes in accelerated stage
Immune system dysfunction
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20
Q

What is incontinentia pigmenti?

A

Ectodermal dysplasia affecting the skin

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21
Q

What is the inheritance pattern of incotinentia pigmenti?

A

X-linked

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22
Q

The most significant findings of incotinentia pegmenti are retinal. What are they?

A

Abnormal blood vessels
RPE mottling
Foveal hypoplasia
RD

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23
Q

What type of inheritance is noted with nevus of OTA?

A

Sporadic inheritance

24
Q

Nevus of OTA involves the dermal distribution of what nerves?

A

V1

V2

25
Q

A nevus of OTA can change in size and color with what events?

A 
Age
Trauma
Puberty
Menarche
Menses
Menopause
Pregnancy
26
Q

What are the iris signs of nevus of OTA?

A

Iris mamillations

TM affected, causing glaucoma

27
Q

Nevus of OTA carries a higher risk of increased IOP, but it is unrelated to what?

A

Degree of angle pigmentation

28
Q

What is the inheritance pattern of vitiligo?

A

Autosomal dominant

29
Q

Vitiligo is hypothesized to have what MOA?

A

Autoimmune

30
Q

What are the ocular findings associated with vitiligo?

A 
Depigmentation of lid
Poliosis
Degpigmentation of uvea
Pigment clumping in periphery
Night blindness
31
Q

What characterizes cicatricial pemphigoid?

A

Sub-epithelial bullae formation

Strictures of the skin and mucosa

32
Q

Cicatricial pemphigoid affects which gender more frequently?

A

Female - starts in 30’s

33
Q

Cicatricial pemphigoid is what type of hypersensitivity?

A

Type II

34
Q

What are the typical ocular findings of cicatricial pemphigoid?

A 
Trichiasis
Keratinization of the tarsal conj
Entropion and lagophthalmos due to ankyloblepharon
Aqueous deficient dry eye
Mucin deficiency
35
Q

What is used to treat cicatricial pemphigoid?

A

Pred acetate

Amniotic membrane

36
Q

Epidermolysis bullosa is a deficiency of which collagen?

A

Collagen 7 in the dermis

37
Q

Which pattern of inheritance of epidermolysis bullosa has the most significant eye findings?

A

Recessive

38
Q

What characterizes epidermolysis bullosa?

A

Blister formation in response to relatively minor trauma

39
Q

Mitten deformity is a systemic sign of what condition?

A

Epidermolysis bullosa

40
Q

Epidermolysis bullosa shows an increased incidence of what cancer?

A

Squamous cell carcinoma

41
Q

What are the common corneal findings of epidermolysis bullosa?

A

RCE
Pannus
Corneal scarring
Exposure keratopathy

42
Q

What is erythema multiforme?

A

Acute, inflammatory vesiculo-bullous reaction of the skin

43
Q

What type of reaction is erythema multiforme>

A

Type IV

44
Q

Erythema multiforme is associated with which gene?

A

HLA B12

45
Q

What is the typical reason for the occurrence of erythema multiforme?

A

Drug/inciting agent

-sulphonamides, contraceptives, HSV, histo, epstein-barr

46
Q

SJS is a reaction to what?

A

Drug

47
Q

What is the typical prodrome of SJS?

A

Fever
Malaise
Sore throat
Arthralgia

48
Q

SJS presents with a severe erythematous maculo-papular rash that is atypical in what way?

A

Not itchy

49
Q

Which is more severe, SJS or TEN?

A

TEN (Toxic epidermal necrolysis)

50
Q

When does SJS become TEN?

A

> 30% of body area

51
Q

What viruses may cause SJS/TEN?

A

Strep
HSV
Mycoplasma pneumoniae

52
Q

What drugs may induce SJS/TEN?

A

PCN
Sulfa
NSAIDs
Anticonvulsants

53
Q

Pemphigus vulgaris is which kind of disease?

A

Autoimmune

54
Q

What type of reaction is pemphigus vulgaris?

A

Type II

55
Q

Pemphigus vulgaris presents with a conjunctivitis that is:

A

Non-scarring

Systemic Disease (12 decks)

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