Cyclosporine

Question 1

MOA

Answer 1

1. Immunosuppressant (Gengraf, Neoral)
   - Used in organ transplant patients
   - Inhibits T cells
2. Anti-inflammatory (Restasis)
   - Thought to decrease inflammation associated with dry eye

Question 2

Indications

Answer 2

• To increase tear production (for patients with Keratoconjunctivitis sicca)
• Kidney, heart, liver transplant
• RA
• Psoriasis

Question 3

Contraindications

Answer 3

Patients with known or suspected hypersensitivity

Question 4

Warning/Precautions

Answer 4

• Don’t touch tip to eye

- Don’t use with contacts (wait 15 minutes before putting contacts back in)

Question 5

Adverse effects

Answer 5

• 17% experience ocular burning
• 1-5% experience conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, visual disturbance
• Post-marketing: hypersensitivity, superficial eye injury

Question 6

Monitoring

Answer 6

No specific recommendations

Question 7

Drug interactions

Answer 7

None noted

Question 8

Toxicity

Answer 8

• Pregnancy category C
• Caution with nursing mothers
• Do not use in patients < 16

Question 9

Brand names

Answer 9

1. Restasis (eye drop)
2. Gengraf (oral)
3. Neoral (oral)