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Drug Delivery II > Exam 1 Tablet Coating > Flashcards

Exam 1 Tablet Coating Flashcards

1
Q

Purposes of tablet coating

A

Protect from environment and increase stability
Mask unpleasant taste/odor
Easier swallowing
Improve product identity
Minimize cross contamination from powder dust
Improve appearance
Reduce abrasion and attrition
Modify drug release (i.e. Enteric coated)

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2
Q

Primary sugar used in sugar coating

A

Sucrose

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3
Q

Disadvantages of sugar coating

A

Skilled manpower

Protracted and tedious

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4
Q

Six main steps in sugar coating:
A. Smoothing, subcoating, color coating, sealing, polishing, printing
B. Sealing, subcoating, smoothing, color coating, polishing, printing
C. Sealing, smoothing, subcoating, color coating, printing, polishing

A

B: sealing, subcoating, smoothing, color coating, polishing, printing

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5
Q

Protects the core from water, and uses alcoholic solutions of resins such as shellac, zein, and cellulose acetate phthalate. May require more than one application

A

Sealing

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6
Q

True or False: Sugar coating often results in a 50-100% increase in weight, that occurs mainly at the subcoating step

A

True

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7
Q

________ is when a sticky coating of gelatin, acacia, and sucrose is applied to sealed tablets, followed by a dusting powder application which reduces stickiness and allows tablet buildup

A

Subcoating

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8
Q

The subcoat is formed from alternate layers of ______ ingredients and ______ components

A

Solution ingredients and powdered components

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9
Q

The tablet must be ________ out before color coating is applied, where a solution containing 60-70% sugar solids and 1-5% titanium dioxide is applied

A

Smoothed out

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10
Q

In the smoothing out process, titanium dioxide acts as a(n) ________.

A

Opacifier

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11
Q

Most critical step in the coating process, that involves multiple applications of materials that are either water-soluble dyes or water-insoluble inorganic pigments and lakes

A

Color coating

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12
Q

Water soluble dye is dissolved in ______ and applied in (small / large) quantities

A

Dissolved in syrup; applied in small quantities

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13
Q

Up to how many individual color applications may be necessary for water-soluble dyes?

A

60

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14
Q

Pigments (opaque) are _______ in syrup

A

Pigments are dispersed in syrup

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15
Q

What results from combining pigments/lakes with an opacifier such as titanium dioxide?

A

Color develops rapidly and dries faster with a thinner coat that results in a shorter processing time

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16
Q

Process used to enhance elegance with the use of a mixture of waxes (water-insoluble) and a cloth lined pan

A

Polishing

17
Q

Spheres made of sugar and starch that mean “without equal” in French

A

Nonpareils

18
Q

How is a film coat applied?

A

Continuously by spraying coating liquid onto a moving mass of product

19
Q

Advantages of film coating

A 
Minimal weight increase (2-3%)
Shorter processing time
Increased efficiency and output
Increase in flexibility and formulations
Improved resistance to chipping
20
Q

What type of coating liquids are used currently?

A

Water-based

21
Q

Materials used in film coating

A

Polymer, plasticizer, colorant, and vehicle

22
Q

What is the purpose of a plasticizer in a film coat?

A

Makes the film flexible

23
Q

Inactive ingredients in film coat

A

Crospovidone, HPMC, polethylene glycol, povidone, titanium dioxide

24
Q

True or False: Polymers on film coats must dissolve in GI fluid to allow release of drug

A

True

25
Q

_______ ______, such as HPMC and methylcellulose, are preferred in film coating

A

Cellulose ethers

26
Q

Glycerin, propylene glycol, citrate esters and phthalate esters are ________ which improves flexibility of the film and adhesion to the substrate

A

Plasticizers

27
Q

Coating that remains intact in stomach, but dissolves and contents are released in intestine

A

Delayed release

28
Q

Variation of coating that releases some drug into the stomach, and remainder is later released in the intestine

A

Repeat-action effect

29
Q

True or False: Most enteric coatings are weak bases

A

False: weak acids

30
Q

Enteric coats are (dissociated / undissociated) in the stomach

A

Undissociated

31
Q

_________ polymers are commonly used in enteric coating

A

Pthalate

32
Q

These coating control the release of the drug so that it is made available to the body over a prolonged period of time

A

Sustained release coating

33
Q

What are common materials used for sustained release coating?

A
  1. Mixtures of waxes and fatty acids
  2. Zein
  3. Shellac
34
Q

Synthetic polymers that are commercially available as aqueous dispersions

A

Latexes

Drug Delivery II (10 decks)

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