5 Transplant Flashcards
(LO)
What’s a self-tissue transferred from one body site to another in the same individual?
What’s tissue transferred between genetically identical individuals?
Tissue transferred between genetically different members of same species?
Tissue transferred between different species?
Auto grafts
Isograft
Allograft
Xenograft
(LO)
In tissue graft rejection, if you block CD8 alone: graft rejected around ___ days
Blocking CD4 alone takes about ___ days.
Blocking BOTH CD4 & CD8 gets rejected around ___ days
15
30
60
(LO) Identify the two stages of tissue graft rejection. What do IFNg and TNFb do in the effector stage?
Sensitization stage
Effector stage
IFNg promotes DTH (Type 4 response), promotes influx of macrophages. Upregulates MHC-I and MHC-II so it INCREASES MHC expression
TNFb is CYTOTOXIC to graft cells
(LO) What are the 3 types of rejection and what mediates them?
Hyper acute rejection
Antibody mediated. MHC-I (type 2)
Acute rejection
Cell-mediated. (Type 4; CD4 driven)
Chronic rejection
(Antibodies and MCH; can be T2 or 4)
(LO) State why transplant patients are at increased risk for complications,
such as infection and malignancy
CMV negative recipients must receive CMV negative blood products
(LO) Given the ABO/Rh and microcytotoxicity test results of a potential
recipient and several donors, identify the best and worst matches for
donor matches for tissue transplant, recognizing the relative
significance of MHC-I (HLA-A, HLA-B), and MHC-II (HLA-DR) on graft
survival; interpret a one-way mixed lymphocyte response assay to
predict the most and least compatible tissues
Slides 26 & 27!!
(TP) what type of rejection is kidney transplant patient experience tender graft and increasing his BUN/CRE on day 7. Indicates a ____ rejection
Hyperacute
Acute
Chronic
ACUTE
(TP) which of the following plays the leading role in transplant rejection?
ABO antibodies
CD4 lymphocytes
CD8 Lymphocytes
Neutrophils
CD4 LYMPH!!!!
(LO) differentiate host-vs-
graft disease and graft-vs-host disease;
Host-vs-graft is where the transplanted tissue is REJECTED by the HOST
Graft vs Host = host is attacked by transplanted T-CELLS. Could be seen in newborns
(LO) Recognize the significance of
immunologically protected sites in transplantation
Our body keeps those areas on lockdown in case what is transplanted gets rejected. If so, our body is protected from the rejection in these sites
(LO) how long does it take to have a Hyperacute rejection? What causes them?
Minutes to 3 days
Previous blood transfusions and their WBCs
Acute tubular necrosis
Renal artery/vein obstruction
Ureteric blockage
(LO) How long does it take to have an acute rejection? Causes?
Within weeks-6months
Mononuclear cells.
T CELL MEDIATED RXN’s (type 4)
(LO) how long does it take to have a chronic rejection? Causes?
6 months -years after transplant
Humoral and cell mediated responses
(Can be type 2 or 4)
