Antipsychotics

Question 1

What conditions do TYPICAL antipsychotics treat?

Answer 1

Psychosis and N/V

Question 2

What is the general MOA for TYPICAL antipsychotics?

Answer 2

D2, H1, anti adrenergic

Question 3

What are some SE for TYPICAL antipsychotics?

Answer 3

Parkinsonian Syndrome, Tardive dyskinesia, Anticholinergics, Extrapyramidal

Question 4

What are the 3 TYPICAL antipsychotics?

Answer 4

1. Chlorpromazine
2. Prochlorproamzine
3. Haldol

Question 5

What hormone may be increased with Chlorpromazine?

Answer 5

Prolactin leading to galactorrhea

Question 6

Which is more potent? Chlorpromazine or Prochlorpromazine and by how much?

Answer 6

Prochlopromazine, 10-20x more potent, but less SE

Question 7

What other conditions can Haldol be used for?

Answer 7

Acute aggression

Question 8

A BAD SE of Haldol that I don’t really understand?

Answer 8

Neuroleptic Malignant Syndrome

Question 9

What condition do ATYPICAL antipsychotics target?

Answer 9

Schizophrenia

Question 10

Absorption of ATYPICAL antipsychotics?

Answer 10

PO, rapid

Question 11

What two hormones do ATYPICALS target?

Answer 11

Dopamine and Serotonin (5HTE)

Question 12

What 3 drugs are ATYPICALS?

Answer 12

1. Clozapine
2. Respiradone
3. Olanzapine

Question 13

Side effects of Respiradone and Olanzapine?

Answer 13

Wt gain, stroke, DM (caution with elderly)

Question 14

Which of the ATYPICALS involve P450?

Answer 14

Respiradone

Question 15

Two BAD side effects of Clozapine

Answer 15

Agranulocytosis

Myocarditis

Question 16

What condition does Lithium target?

Answer 16

Bipolar/ MANIAAAAA

Question 17

What hormones does Lithium target?

Answer 17

NE and Glutamate

Question 18

Does Lithium have a small or large therapeutic index?

Answer 18

Small-so toxicity is an issue

Question 19

Why does lithium cause decreased mental capacity?

Answer 19

Less responsive to ADH

Question 20

Why is compliance with lithium difficult?

Answer 20

Wt gain, aint nobody want to be fat