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RUSVM Virology Spring17 > Bunyarviridae > Flashcards

Bunyarviridae Flashcards

1
Q

Where is the family Bunyarviridae isolated from?

A

Uganda

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2
Q

What are the five genera of bunyarviridae?

A 
orthobunyavirus
phebovirus
nairovirus
hantavirus
tospovirus
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3
Q

Which genera are arboviruses (arthropodborne virus)

A

Orthobunyavirus
phebovirus
nairovirus

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4
Q

When are bunyaviruses the most active (weather)?

A

***RAINY SEASON

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5
Q

T/F: Bunyaviruses are not sensitive to heat and acid

A

FALSE

They are sensitive to heat and acid - also inactivated by lipid solvents. detergents, disinfectants

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6
Q

What sense (negative or positive) RNA are bunyaviruses composed of?

A

negative sense

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7
Q

What is special about the genome of bunyaviruses?

A

It is segmented (3 segments)

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8
Q

What are the 3 segments of the bunyavirus genome and what do they encode for?

A

L: RNA dependent RNA polymerase

M: Glycoproteins - Gn, Gc

S: Nucleocapsid protein

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9
Q

What bunyavirus is present in North America and of zoonotic concern? How is it transmitted?

A

La Crosse Virus - transmitted via mosquitoes

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10
Q

Who are the hosts of the Akabane Virus?

A

Small ruminants and cows

*Africa, Asia, Japan

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11
Q

What animals are the most susceptible to the Akabane Virus?

A

Pregnant animals (mostly cows)

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12
Q

What clinical signs will be seen in animals infected with the Akabane virus? Signs in the fetus or new born?

A

No apparent signs in adults

Fetus - death and abortion

Neonates: hydranencephaly (virus replication in CNS)
Arthrogyposis (virus replicates in the muscle)

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13
Q

T/F: If a neonate survives being born with Akabane virus, it will gain immunity

A

False - adults will gain immunity after infection, but the fetus will not

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14
Q

Is these a vaccine for akabane virus?

A

Vaccine is available

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15
Q

What genera does the Rift Valley Fever Virus belong to?

A

Phebovirus

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16
Q

What is the “silent cycle” of the Rift valley fever virus?

A

During dry season or between heavy rainful

Rain will increase the amount of mosquitoes to spread the virus

17
Q

Who are the hosts of the rift valley fever virus?

A

sheep/goats/cattle

18
Q

T/F: In pregnant ewes and cows with Rift valley fever virus, 90-100% will abort

A

TRUE

19
Q

T/F: Adult cows have more severe disease than goats/sheep when infected with Rift valley fever virus

A

FALSE
Mortality in cows: 10-30%
Mortality in lambs: 90% Mortality in adult sheep: 20-60%

20
Q

Where does the rift valley virus replicate inside the host?

A

lymphoreticuloorgans

21
Q

What are the most common causes of death associated with rift valley fever virus?

A

Hepatic necrosis and renal failure

22
Q

Where do bunyaviruses replicate in the cell?

A

cytoplasm

23
Q

T/F: Rift valley fever virus is zoonotic

A

TRUE

RUSVM Virology Spring17 (23 decks)

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