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RUSVM Virology Spring17 > Reoviridae > Flashcards

Reoviridae Flashcards

1
Q

Reoviruses are _________ stranded, _________ RNA.

A

Double stranded, SEGMENTED

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2
Q

What kind of symmetry do reoviruses have?

A

Icosahedral

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3
Q

T/F: Reoviruses are enveloped

A

FALSE

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4
Q

T/F: Reoviruses undergo genetic reassortment

What is genetic reassortment?

A

TRUE

When two different viruses mix and match segments within a shared host to create a new virus

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5
Q

Where in the cell do reoviruses replicate?

A

Cytoplasm

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6
Q

T/F: Bluetongue virus is a highly contagious, non infections virus

A

FALSE

Bluetongue is an infectious, non-contagious virus

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7
Q

If you have a patient that you suspect has bluetongue, what should you do?

A

REPORT IT!!

REPORTABLE / List A virus (transport restrictions)

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8
Q

What type of sheep are most commonly susceptible to Bluetongue?

A

European breeds (fancy wool sheep)

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9
Q

T/F: Cattle and goats can contract bluetongue virus

A

TRUE

symptoms may be less severe

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10
Q

How is bluetongue transmitted?

A
  1. Culicoides Sonorensis (most common MOT/Spp of culicoides)
  2. Trans-placental
  3. Venereal
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11
Q

What path does bluetongue virus take once it gets in the body?

A

Infected by midge –> replicates in vascular and lymph endothelium –> travels to Lungs, LN, and spleen for replication –> viremia

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12
Q

T/F: Bluetongue virus may cause lameness in sheep

A

TRUE - inflammation of the coronary bands is a clinical sign

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13
Q

What are some modes of pathogenesis and clinical signs of bluetongue virus?

A

PATH: Damage to vascular endothelium, necrosis of tissues/organs supplied by damaged arteries, edema, hemorrhage

signs: fever, mucopurulent nasal d/c and crust around nostrils/mouth, buccal and dental pad erosions, cyanotic (blue) tongue*, inflammation of coronary bands, facial edema

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14
Q

T/F: Cattle typically get the chronic form of bluetongue

A

FALSE

acute: congestion and hemorrhage of nose, stomatitis, mucopurulent nasal discharge

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15
Q

T/F: There are vaccines available for bluetongue virus

A

TRUE

Live

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16
Q

What is an important form of control for most reoviruses

A

VECTOR CONTROL

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17
Q

What is the mortality rate of African Horse Sickness?

A

HIGH 75-90%

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18
Q

What genus do African Horse Sickness and Bluetongue belong to?

A

Orbivirus

19
Q

Who gets infected by African Horse Sickness?

A

Horses-donkeys-mules

*rare occasions - dogs from eating infected meat

20
Q

African horse sickness virus is composed of _____ segments of RNA. There are ____ known serotypes.

A

10 segments

9 serotypes

21
Q

Who are the vectors for AHS?

A

Culicoides imicola & C. bolintinos

22
Q

Who is an asymptomatic carrier of AHS?

A

Zebras

23
Q

What clinical signs are seen in the Dunkup form of AHS and when does it occur?

A

ACUTE phase

Pulmonary: frothy nasal discharge and froth in trachea, pulmonary edema and petechia of the lungs

24
Q

What clinical signs are seen in the Dikkop form of AHS and when does it occur?

A

SUBACUTE

Cardiac: edema of the head and eyelids, hydroperitoneum, congestion in conjunctiva, serosal petechia, edema in the mucosa of the colon

25
Q

How do you treat African horse sickness?

A

CULL

Prevention by vector control or vaccine

26
Q

Rotaviruses have _____ segments of ________ stranded RNA. They are broken down into ____ groups (A-H).

A

11 segments
double stranded
8 groups

27
Q

*What group of rotaviruses are he most important cause of diarrhea in young animals and humans?

A

RVA

28
Q

VP7 are grouped into ____ genotypes.

VP4 are grouped into ____ genotypes.

A 
VP7 = G
VP4= P
29
Q

T/F: Rotaviruses are very stable in the environment

A

TRUE

30
Q

What is the most common mode of transmission of rotaviruses?

A

FECAL ORAL ROUTE

31
Q

Where do rotaviruses replicate in the body?

A

Enterocytes of intestinal vili = malabsorption Dhr

increase calcium in the cell due to replication will also induce secretory dhr

32
Q 
In what age groups are these animals effected by rotavirus dhr most commonly?
Calves
Lambs
Piglets
foals
A

Calves: 1-3 weeks
Lambs: less than 3 weeks
Piglets: 1-5 weeks
foals: anytime?

33
Q

T/F: Rotaviruses are self-limiting

A

TRUE

34
Q

T/F: If a horse has African horse sickness, you need to report it right away

A

TRUE - List A virus

35
Q

Is rotavirus zoonotic?

A

YES!!

36
Q

What are some dx methods used for rotavirus testing?

A

PAGE, ELISA, Electron microscopy, PCR

37
Q

If you decide to vaccinate for rotavirus, who do you vaccinate?

A

Horses and cattle - while pregnant so immunity will be passively transferred to the offspring

38
Q

What genus does the avian reovirus belong to?

A

Orthoreovirus

39
Q

What is the avian reovirus’s claim to fame?

A

Number one cause of lameness in poultry!

Causes arthritis and tenosyvitis

40
Q

What are the primary route of transmission of the avian reovirus?

A

**fecal oral route

also transovarial and inhalation

41
Q

What chickens are most effected by avian reovirus?

A

broilers

42
Q

What is the pathogenesis of avian reovirus?

A

replication in the intestines –> spread via blood stream to joints –> specifically hock joint –> severe inflammation and synovial fluid - can cause rupture of the gastrocnemius

43
Q

How is the avian reovirus prevented?

A

Modified and live vaccines

Vaccines are admin to layers to pass immunity to chicks
sometimes chicks are vaccinated

RUSVM Virology Spring17 (23 decks)

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