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FD BLOCK > 5. Histology of connective tissue > Flashcards

5. Histology of connective tissue Flashcards

1
Q

Loose connective tissue

A

around organs

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2
Q

Dense connective tissue

A

ligaments, tendons, skin

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3
Q

Cartilage

A

respiratory tract, ear

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4
Q

Bone

A

skeleton, skull

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5
Q

Fibroblasts

A

spindle shaped cells

produce the extracellular matrix

Central nucleus

basophyllic cytoplasm due to lots of ER

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6
Q

GAGs

A

large unbranched polysaccharides

repeating disaccharide units

open coil formation

electrostatically linked

acidic or negatively charged

hydrophylic

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7
Q

4 types of fibrillar proteins

A

1) Collagen
2) Elastin
3) Fibrillin
4) Fibronectin

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8
Q

Collagen

A

most abundant protein in the human body

20 different types

secreted by fibroblasts

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9
Q

Elastic fibres

A

formed from elastin and fibrillar secreted by fibroblasts

proteins secreted in to ECM

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10
Q

Laminin

A

component of basement membranes

binds integrins on cell membranes, type IV collagen

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11
Q

Enactin

A

component of basement membranes

binds laminin and type IV collagen

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12
Q

Tenascin

A

found in embryo

involved in cell migration

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13
Q

Where is Basement Membrane found

A

epithelia

glomeruli of kidney

muscle

nerves

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14
Q

BM composition

A

1) type IV collagen
2) fibronectin
3) heparan sulphate
4) laminin
5) enactin

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15
Q

Brown adipose

A

found in the newborn

metabolises fat to produce heat

Lipid stored in numerous droplets

rich network of capillaries

Tissue arranged in lobules

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16
Q

White adipose

A

stores fat

acts as heat/shock insulator

Lipid stored in a large single droplet

Nucleus and cytoplasm are restricted to the rim of the cell

17
Q

Diseases of Collagen

A

Point mutation in gene for collagen I
osteogenesis imperfecta
fragile bones

Other mutations in gene for collagen I
Ehlers Syndrome
abnormally stretchy skin and joint laxity

18
Q

Diseases of Connective tissue

A

Amyloidosis

amyloid deposited in ECM

tissue dysfunction

19
Q

Systemic diseases

A

Lupus erythematosis

Autoimmune disease

patients develop antibodies to dsDNA

mainly affects skin and kidneys

FD BLOCK (18 decks)

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