(28) Hypersensitivity III

Question 1

(Type III Hypersensitivity)

1. IgG antibodies attack what? resulting in what?
2. Why is the immune complex a problem?

Answer 1

1. foreign antibodies in a soluble form; immune complexes and extensive inflammation
2. deposit in various locations in the body; then activate neutrophils and macrophage which release alot of proinflammatory factors

Question 2

look at this slide

Question 3

1–4. What are 4 things that can cause Type III Hypersensitivity?

Answer 3

1. serum sickness
2. drug induced
3. infectious disease
4. arthus reaction (this is actually a test)

Question 4

(Things that can Cause Type III hypersensitivty)

(serum sickness)

1. administrations of what? typically serum from what?
2. Will it get worse the second time? why?

Answer 4

1. anti-venoms; serum from horses immunized with a particular venom

*basically sickness caused by the fact that there are a bunch of proteins injected with the anti-venom from another animal

2. yep; they have developed antibodies against anti-venom proteins

Question 5

(Things that can cause Type IIi)

(Drug INduced)

1. antibody response to what?

Answer 5

1. certain antibiotics (penicillin)

*here you are getting antibody formation to antibiotic itself (form immune complexes)

Question 6

(Things that can cause Type IIi)

Infectious Disease/Vaccination

to sever - a lot of bacteria - alot of antibodies produced - bind to bacteria and debris (forms immune complexes)

same basic thing with vaccination - formation of antibodies

Question 7

(Type IIi)

(Clinical Manifestations)

1. Occur quickley? as fast as type 1?

Answer 7

1. yes (within 1 to 2 hours); no

Question 8

Arthus reaction

just look at picture