CHAPTER 226 HIV

Question 1

The hallmark of HIV disease is a profound immunodeficiency resulting primarily from a progressive quantitative and qualitative deficiency of ___________ occurring in a setting of polyclonal immune activation.

Answer 1

the subset of T lymphocytes referred to as helper T cells

Question 2

The helper subset of T cells is defined phenotypically by the presence on its surface of the _____ which serves as the primary cellular receptor for HIV.

Answer 2

CD4 molecule

Question 3

serves as the primary cellular receptor for HIV.

Answer 3

CD4 molecule

Question 4

A co-receptor must also be present together with CD4 for efficient binding, fusion, and entry of HIV-1 into its target cells . HIV uses two major co-receptors, _______, for fusion and entry;

Answer 4

CCR5 and CXCR4