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Pathopharmacology Exam 1 Review > FINAL DRUGS > Flashcards

FINAL DRUGS Flashcards

1
Q

Example of a Hydantoin

A

phenytoin (Dilantin)

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2
Q

Example of a Iminostillbene drug

A

carbamazepine (Tegretol)

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3
Q

Ending of Iminostillbenes

A

-azepine

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4
Q

Anti-epileptic drug that causes bone marrow suppression, skin rash, liver toxicity, pancreatitis, and may be given with phenytoin or phenobarbital to increase levels of both meds.

A

Valproic Acid (Depakote)

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5
Q

Anti-epileptic drug that causes stevens-johnsons skin rash, bone marrow suppression, auto induction and takes more than 2 months to start therapeutic effects.

A

carbamazepine (Tegretol)

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6
Q

Anti-epileptic drug that can cause gingival hyperplasia, and must be diluted with normal saline in an IV and must be given slow.

A

phenytoin (Dilantin)

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7
Q

Drugs not to give with hemorrhagic stroke. Must be given within 3 hours of CVA.

A

Thrombolytic drugs

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8
Q

Anticholinesterase Drugs:

A

donepezil (Aricept)
rivastigmine (Exelon)
galantamine (Razadyne)

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9
Q

Drugs that treat Alzheimers Disease

A

Anticholinesterase Drugs

NMDA Receptor Antagonists [memantine (Namenda)]

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10
Q

Drugs that prevent cholinesterase (AChE) from breaking down acetylcholine (ACh) causing increased ACh.

A

Anticholinesterase Drugs

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11
Q

Drugs that inhibit the activity at NMDA receptors to slow disease process and decrease or stop cognitive degeneration.

A

NMDA Receptor Antagonists

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12
Q

Drugs that inhibit actions of MAO-B enzymes that break down dopamine resulting in increased dopamine.

A

Selective MAOI Therapy/ MAO-B Inhibitors

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13
Q

Drugs that cause the release of dopamine from storage in basal ganglia

A

Dopamine Modulators

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14
Q

Drugs that stimulates dopamine receptors to = the same effect as if dopamine had been bound.

A

Dopamine Receptor Agonists

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15
Q

The precursor of dopamine that crosses the blood brain barrier before it is broken down into dopamine which increases dopamine in the CNS

A

Levodopa

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16
Q

drugs that inhibit COMT enzymes from breaking down dopamine

A

COMT Inhibitors

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17
Q

Drugs that block the effect of Each at cholinergic receptors

A

Anticholinergics

18
Q

Example of a NMDA Receptor Antagonists

A

memantine (Namenda)

19
Q

Example of Selective MAOI Therapy drugs/ MAO-B Inhibitors

A

selegiline (Eldeprly)

rasagiline (Azilect)

20
Q

Dopamine Modulators

A

amantadine (Symmetrel)

21
Q

Dopamine Receptor Agonists

A

pramipexole (Mirapex)

ropinirole (Requip)

22
Q

Used to treat Parkinson’s Disease int he early stages

A

amantadine (Symmetrel)

23
Q

Drug used to treat Restless Leg Syndrome. Drugs to use alone when treating Parkinsons before need to Levodopa or adjunct w/Levodopa.

A

Dopamine Receptor Agonists: Mirapex + Requip

24
Q

1 Therapy for Parkinsons Disease

A

Levodopa

25
Q

Adjunct with levodopa when on/off phenomenon occurs.

A

COMT Inhibitors : Comatan + Tasmar

26
Q

Contraindications of COMT Inhibitors: Comatan + Tasmar

A

Liver Dysfunction

Alcoholism

27
Q

Contraindication of Anticholinergics : Cogentin

A

Glaucoma
Kidney Failure
Constipation

28
Q

Adverse effects of Anticholinesterase drugs

A 
Bradycardia
hypotension
fainting
pupillary constriction
Bronchial Constriction
Cholinergic Crisis
SLUD
29
Q

Adverse effects of Selective MAOI Therapy/MAO-B Inhibitors

A

Hypertensive crisis after consuming tyramine containing foods

30
Q

Adverse effects of Dopamine Modulators

A

Dizziness
Insomnia
Nausea

31
Q

Adverse effects of Dopamine Receptor Agonists

A

Orthostatic/Postural hypotension
Dark urine/sweat
paranoia, hallucinations
dyskinesia/spasticity

32
Q

Adverse effects of COMT Inhibitors

A

Nausea/Vomiting
Dark Urine
Liver Failure
Dyskinesia/Spasticity

33
Q

adverse effects of anticholinergics

A 
Tachycardia
hypertension
pupillary dilation
bronchial dilation
urinary retention
dry mouth
constipation
hyperthermia
blurred vision
Cant SSSS
34
Q

Drug interaction of Dopamine Receptor Agonists

A

Protein

Vit B6

35
Q

Drug interactions of Selective MAOI Therapy drugs/ MAO-B Inhibitors

A

Tyramine

36
Q

Drug interactions of Dopamine Receptor Agonists

A

CNS Depressants (alcohol + opioids)

37
Q

Antidote to Anticholinesterase drugs

A

Atropine

38
Q

drug of choice for young parkinson’s patients. first or second line therapy for elderly patients.

A

Dopamine Receptor Agonists (Mirapex + Requip)

39
Q

this drug can be used as an adjunct to levodopa for “off periods”. Can be used to reduce dyskinesia associated with later stages of Parkinson’s Disease

A

Dopamine Receptor Agonists (Mirapex + Requip)

40
Q

Levodopa is no longer effective after how long?

A

5-10 years of use

41
Q

drug that prevents the breakdown of levodopa in the PNS to decrease adverse effects

A

carbidopa-levodopa (Sinemet)

Pathopharmacology Exam 1 Review (6 decks)

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