6. Syphilis and Chancroid Flashcards Preview

ID > 6. Syphilis and Chancroid > Flashcards

Flashcards in 6. Syphilis and Chancroid Deck (14):
1

T. pallidum MOA

Adheres to vascular endothelium - binds fibronectin

2

Primary syphillis

Painless infectious chanre (not confined to genitals), painlesss bilateral lymphadenopathy. ~3wk incubation. Resolves 2-8 wks.

3

Secondary syphillis

6wks to months after 1o sx. rash involving palms and soles. condyloma lata from coalsced papular lesions. generalized lymphadenopathy. Resolves in 2-10 wks.

4

Tertiary

1-50 yrs after 1o inf. = reactivation of latent syphilis. Late neurosyphilis, cardiovascular syphilis (obliterative endarterisits, anueurysm, asc aorta), late benign syphilis (gummas - granuloma nodules of skin, cartilage and bone)

5

Neurologic syphilis

Occurs at any stage. Symptomatic early NS - within 1st yr after infection. presents as meningitis. Late NS - ~10 yrs after 1o inf., meningovascular, parencymatous

6

Late neurosyphilis

1. Meningiovascular: endarteritis, trokes
2. Parenchymatous: nerve destruction - tabes dorsalis, general paresis, Argyll Robertson pupil

7

Syphilis in pregnancy

Miscarriage, preterm delivery.

8

Congenital syphillis

Rhinitis, saddle nose, skin eruptions, hepatosplenomegaly, pseudoparalysis, lymphadenopathy, and anemia. 3o syphilis complications.

9

Syphilis diagnosis

1. Non treponemal: VDRL, RPR. Titers. False positives/negative (prozone)
2. Treponemal - detect Abs, + for life.

10

Syphilis treatment and prevention

ALWAYS penicillin but Penicillin allergic patients with 1o, 2o, 3o, latent, or cardiovascular syphilis, long courses of erythromycin, doxycycline, or tetracycline may be employed. Infection does not confer protection.

11

Haemophilus ducreyi xteristics

Gram - facultative anaerobe coccobacillus. Sexual contact. Incub 3-10 days.

12

Haemophilus ducreyi symptoms

Painful ragged chancres, suppurative inguinal adenopathy

13

Haemophilus ducreyi diagnosis

History and PE largely

14

Haemophilus ducreyi treatment

Azithromycin, ceftriaxone, erythromycin or ciprofloxacin