Cannabis and MS Flashcards
1
Q
What is the pathophysiology of MS?
A
Multifocal white and grey matter lesions alongside the loss of oligodendrocytes
2
Q
When does MS usually develop?
A
20-40 years of age
3
Q
What are the symptoms of MS?
A
Pain, spasms, tremor, incontinence, cognitive deficits, movement deficits. Due to conduction block, demyelination and loss of axons/neurones and synaptic plasticity
4
Q
How may cannabinoids be used in the treatment of MS?
A
Cannabinoids induce hyperpolarisation which limits the capacity of cells to generate actions potentials, so prevents spasticity due to over-excitation or lack of neural inhibition
5
Q
How may baclofen be used in the treatment of MS?
A
A GABA-b agonist to encourage inhibition –> treatment of tremor and spasticity
