Antibiotic: Cell Wall Inhibitors

Question 1

This drug inhibits stage 4 cross-linking of polysaccharide chains to inhibit cell wall synthesis

Answer 1

PCNs

Question 2

Type 1 PCNs are highly effective against gram + bacterial. What are they? What do they treat?

Answer 2

• PCN G, PGN V

- corneal ulcers

Question 3

Type 2 PCNs are resistant to Penicillinase. What are they?

Answer 3

Methacillin, Oxacillin, Dicloxacillin, Nafcillin, Cloxacillin

Question 4

What do type 2 PCNs treat?

Answer 4

Ulcer, internal hordeolum, Acute Dacryocystitis, Endophthalmitis

Question 5

Type 3 PCNs have extended spectrum activitiy. What are the 2 type 3 PCNs?

Answer 5

Amoxicillin and Ampicillin

Question 6

T or F: Type 3 PCNs are ineffective against most staph infections.

Answer 6

True

Question 7

What is the DOC for gonorrhea/gonorrhea conjunctivitis?

Answer 7

Ceftriaxone

Question 8

What is the DOC for Pseudomonas Aeruginosa?

Answer 8

Ceftazidime

Question 9

What is the most commonly used cephalosporin?

Answer 9

Cephalexin (Keflex) = 1st generation

Question 10

Treatment for Staph Aureus and Surgical prophylaxis is provided by what cephalosporin?

Answer 10

Cefazolin

Question 11

What are the clinical uses for Keflex?

Answer 11

Preseptal Cellulitis, Endophthalmitis

Question 12

What antibacterial does these 4 things:

a. inhibits stage 4 of cell wall synthesis
b. alters permeability causing lysis of cell wall
c. inhibits protein synthesis
d. releases autolysis

Answer 12

Cephalosporins

Question 13

What are the 5 ADRs of cephalosporins?

Answer 13

1. Allergy
2. Cross Sensitivity w/ PCNs
3. Vitamin K deficiency
4. Superinfection
5. Renal Impairment

Question 14

Vancomycin inhibits what stage of bacterial cell wall synthesis? How?

Answer 14

• Stage 2

- Binds to pentapeptide to inhibit elongation during cell wall devleopment

Question 15

Vancomycin is reserved for life-threatening/blinding infections such as what?

Answer 15

MRSA, Endophthalmitis

Question 16

What are the 3 main ADRs of Vancomycin use?

Answer 16

1. Red Man Syndrome
2. Nephrotoxicity
3. Ototoxicity

Question 17

Bacitracin inhibits what stage of bacterial cell wall synthesis?

Answer 17

Stage 3

Question 18

Bacitracin is primarily used as a topical ointment. Name the 2 ointments bacitracin is found.

Answer 18

Polysporin = Polymyxin B + Bacitracin

Neosporin Ung = Polymyxin B + Baci. + Neomycin

Question 19

Polymyxin B and Gramacidin is a ______ detergent that forces fluid into the cell land causes it to swell and rupture

Answer 19

Cationic

Question 20

Polymyxin B has gram ____ coverage.

Answer 20

gram negative

Question 21

Gramacidin has gram ____ coverage.

Answer 21

gram positive