Antibiotic: Interfere w/ DNA Synthesis

Question 1

What 2 enzymes to FQs inhibit?

Answer 1

DNA Gyrase + Topoisomerase IV

Question 2

This enzyme prevents DNA from uncoiling to allow transcription and replication.

Answer 2

DNA Gyrase

Question 3

This enzyme doesn’t allow replicated DNA to separate to its respective daughter strands/cells.

Answer 3

Topoisomerase IV

Question 4

What is the age restriction for FQs?

Answer 4

Pt must be 18+

Question 5

What are the ADRs of FQs?

Answer 5

1. Cartilage toxicity, joint swelling, tendonitis

2. Increase muscle weakness in pts wit hMG

Question 6

What was the first commercially available FQ?

Answer 6

Ciprofloxacin

Question 7

What are the 3 types of 2nd gen. FQs?

Answer 7

1. Ciprofloxacin
2. Norfloxacin
3. Ofloxacin

Question 8

Name a 3rd generation FQ.

Answer 8

Levofloxacin

Question 9

Levofloxacin has increased ______ which penetrates the cornea to aqueous readily.

Answer 9

solubility

Question 10

What are the 3 types of 4th gen. FQ?

Answer 10

1. Moxifloxacin
2. Gatifloxacin
3. Besifloxacin

Question 11

What are the 2 medications associated with Moxifloxacin?

Answer 11

Moxeza and Vigamox

Question 12

Moxeza is good for what age? What is the pregnancy category?

Answer 12

4mo. and older

Preg. Cate. C

Question 13

Moxeza contains an xanthan gum vehicle and is ___x greater than Vigamox

Answer 13

1.8x

Question 14

Vigamox is good for what age?

Answer 14

1 yo +

Question 15

Gatifloxacin is Zymaxid. What pregnancy category is it?

Answer 15

Pregnancy Cat. C

Question 16

Besifloxacin (i.e. Besivance) is the DOC for what?

Answer 16

Corneal Ulcers

Question 17

The bacterial resistance to Besifloxacin is ___ due to no systemic counterpart.

Answer 17

low

Question 18

What are the ADRs for Besifloxacin?

Answer 18

1. Hyperemia
2. Blurred Vision
3. Pain
4. Irritation
5. HA