Autonomic Pharmacology Flashcards
Location of nicotinic (NN) receptors
PANS and SANS ganglia
Adrenal medulla
Location of nicotinic (NM) receptors
skeletal muscle motor end plate
location of muscarinic receptors
Organs or tissues innervated by post-ganglionic nerves of PNS and thermoregulatory sweat glands of SNS
Location of adrenoceptors
Organs or tissues innervated by post-ganglionic nerves of SANS
T/F: Nicotinic (NM) receptors are not exclusively ANS receptors since NM can be present in somatic voluntary muscles
True
T/F: Catecholamines have more of a neuronal effect rather than humoral or hormonal
False
Potential targets for pharmacologic therapy
Synthesis Storage Release Termination of action Receptor effects
Location of norepinephrine
most adrenoceptors in innervated tissues
Location of dopamine
D1 receptors in renal vasculature
Neurotransmitter from the adrenal medulla which activates most adrenoceptors whether or not the tissues are innervated
Epinephrine
Neurotransmitters located in ENS and AND fibers in GI tract
Serotonin (5-HT)
Purines
Peptides
Blocks sodium-dependent membrane choline transporter (CHT)
Hemicholiniums
Blocks vesicle-associated transporter (VAT)
Vesamicol
Blocks calcium receptors in fusion proteins of the presynaptic membrane
Botolinum toxin (Botox)
Major mechanism of Ach termination
Acetylcholinesterase (AchE)