Hematology

Question 1

Physiologic anemia of infancy

Lasts?

Patho?

Answer 1

8-12 weeks

EPO downregulation

Question 2

Physiolgoic anemia of prematurity

Hgb levels?

Treatment

Answer 2

7-9

needs transfution, EPO

Question 3

IDA is most common anemia in ____ Months of age?

Answer 3

9-24months

Question 4

At ___mg/dL RBC compensatory mechanism dont work anymore

Answer 4

5mg/dL

Question 5

Diagnosis of IDA

1. Reticulocyte count
2. ______ cytic
3. _____ chromic
4. _____ RDW
5. ______ serum iron
6. ______ serum ferritin
7. ______ TIBC

Answer 5

1. Low reticulocyte count
2. microcytic
3. hypochromic
4. High RDW
5. Low serum iron
6. Low serum ferritin
7. High TIBC

Question 6

Prevention of IDA

1. Premature infants
2. 4-11mo
3. 1-5 yo
4. Adolescents

Answer 6

1. 7.5mg OD 3 months
2. 15mg OD for 3 months
3. 30mg OD
4. 60mg + folic acid

Question 7

Response to iron therapy

1. 12-24 hours
2. 26-28 hours
3. 48-72 hours
4. 4-30 days
5. 1-3 months

Answer 7

1. Subjective improvements
2. Intial bone marrow response
3. Reticulocytosis
4. Increasing hgb levels
5. Repletion of iron stores (cbc time)

Question 8

Seen in the PBS of alpha thalassemia?

Answer 8

1. Target cells and heinz bodies.

Question 9

When does sickle cell anemia usually occur?

Answer 9

After 6months of life. When HbS replaces HbF

Question 10

Seen in PBS for sickle cell anemia?

Answer 10

1. Sickle cells with howell jolly bodies

Question 11

Definitive diagnosis of sickle cell anemia?

Answer 11

HbS on Hb electrophoresis.

Question 12

Cut off for platelet transfusion?

Answer 12

50,000

Question 13

Platelet <20,000 =

Answer 13

Spontaenous bleeding

Question 14

Platelet transfusion in ITP yes or no? Why

Answer 14

No, platelets will just be destroyed.

Question 15

Hemophilia A mutation

Treatment

Answer 15

Factor viii x linked recessive, more common

Factor 8, cryoprecipitate or FFP

Question 16

Hemophilia B mutation

Treatmnet

Answer 16

Factor IX christmas disease, x linked recessive

Factor IX, cryoSUPERNATE, FFP

Question 17

Most common hereditary bleeding disorder

Answer 17

VWD

Question 18

Most common most serious congenital coagulation factor deficiency

Answer 18

Hemo A

Question 19

Most common hereditary hypercoaguable disorder?

Answer 19

Factor V laden

Question 20

Hallmark of hemophilia

Answer 20

Prolonged bleeding of wounds.

Question 21

Joint hemmorhage occur where usually?

Answer 21

Ankle

Question 22

Treatment for mild vWD

Answer 22

Desmopressin, pushes endothelial cells to release vwf

Question 23

WILMS tumor is associated with

Answer 23

1. Neurofibromatosis
2. Beckwith Wiedemann syndrome (hemihypertrophy, visceromegalym, macroglossia)
3. WAGR syndrome (wilms, aniridia, genito urinary abnormalities, mental retardation)

Question 24

Treatment of Wilms tumor?

Answer 24

1. Nephrectomy + post surgical chemo

Question 25

Worst prognosis for Wilms tumor

Answer 25

1. > 500grams
2. St III and IV
3. Anaplastic type.

Question 26

Differentials for small round blue cell tumor?

Answer 26

Wilms
Acute leukemia
Rhabdomyosarcoma
Mesothelioma/medulloblastoma
Ewing sarcoma
Retinoblastoma
Primitive neuroectodermal tumor. 
Neuroblastoma

Question 27

Neuroblastoma sites?

Answer 27

1. Adrenal glands

2. Sympathetic ganglia

Question 28

Neuroblastoma is the most common?

Answer 28

Extracranial tumor.

Question 29

Neuroblastoma is associated with

Answer 29

Tuberous sclerosis
Pheychromocytoma
Neurofibromatosis.
Hirschprung disease

Question 30

Definitive diagnosis of aplastic anemia?

Answer 30

Hypocellular marrow

Question 31

Most common childhood malignancy?

Answer 31

Acute lymphoblastic leukemia

Question 32

Most common solid tumor of childhood?

Answer 32

Brain tumors

Question 33

Most common solid tumor outside CNS?

Answer 33

Neuroblastoma

Question 34

Most common soft tissue tumor?

Answer 34

Rhabdomyosarcoma

Question 35

Malignancy with highest mortality?

Answer 35

Brain PNET