ch 28 dx

Question 1

plaques of alz dis

Answer 1

Congo red stain

Question 2

Metachromatic leukodystrophy

Answer 2

toluidine blue since the sulfitides use metachromasia to shift the absorbance spectrum of the dye = metachromasia

Question 3

Tuberous sclerosis complex

Answer 3

Stain for both tuberin and hamartin

Question 4

Von Hippel-Lindau Dz

Answer 4

Stain for inhibin

Question 5

Primary CNS lymphoma

Answer 5

hooping: the infiltrating cells are separated from one another by silver staining material

Question 6

primary germ cell tumors

Answer 6

markers α-fetoprotein and β-hcg

Question 7

medullobalstoma

Answer 7

Ki-67

Question 8

Atypical teratoid/rhabdoid tumors

Answer 8

epithelial membrane ag, vimentin, smooth muscle actin and keratins.

Question 9

Multiple system atrophy (MSA)

Answer 9

inclusions in oligodendrocytes show α-syn and ubiquitin with silver stains.

Question 10

tangles of Alz dis

Answer 10

basophilic fibrils with H/E staining or silver (Bielschowsky) staining

immunohistochemistry directed against tau