Antineoplastics

Question 1

Resistance of imatinib could arise by means of which of the following

BRA/ALB gene amplification

A mutation in ALB tyrosine kinase

Induction of ABC transporter P-170, the product of MDR-1 gene

Answer 1

All 3!!!

Question 2

What does -nib mean?

Answer 2

Nibs are inhibitors!

Question 3

-tinibs

Answer 3

inhibitors of kinases

Question 4

-anibs

Answer 4

inhibitor of angiogenesis

Question 5

-rafenibs

Answer 5

inhibitors of raf kinase (serine/threonine)

Question 6

Toxicity from checkpoint inhibitors prominently includes

Nephrotoxicity

Hepatotoxicity

Autoimmunity

Vertigo

Insomnia

Answer 6

Autoimmunity

Question 7

Most classical antineoplastic agents function by

Answer 7

directly or indirectly interefering with nucleic acid synthesis

Question 8

Classical antineoplastics

Answer 8

Act relatively nonspecific. This means that you can have a lot of toxicity to any replicating cell population (bone marrow, GI, hair follicles)

Bone marrow suppression most often limiting step

Ulceration of oral and GI mucosa

Alopecia

Impaired wound healing

Crystalluria due to hyperuricemia