Immune System Meds

Question 1

cyclosporine (Sandimmune)

Answer 1

Specific immunosuppression drug for organ transplants by inhibiting lymphocytes
Side effects, Malignant HTN, Renal Disease, UV exposure

Question 2

azathioprine (Imuran)

Answer 2

Immunosuppressant - inhibits purine synthesis in cells. Less specific than cyclosporine. Used for transplants
Side effects: D&V, hepatotoxicity, severe leukopenia, bone marrow suppression

Question 3

mycophenolate (Cellcept, Myofortic)

Answer 3

Inhibits inflammatory response mediated by immune system. Prophylaxis for organ rejection. DO NOT USE WITH azathioprine
Side effects: HTN, chest pain, D&V, UTIs & rash

Question 4

prednisone

Answer 4

Corticosteroid - Decreases inflammation. Used for immunosuppression.
Side effects - Cushingoid symptoms, embolism, depression, flushing, sweating

Question 5

basiliximab (Simulect)

Answer 5

Monoclonal Antibody (interleukin-2 antagonist)
Blocks interleukin 2 receptor on selective activated T-Lymphocytes.  (These are antibodies made in an animal)