Liver and Biliary System Flashcards
1
Q
contrast the secretion of the canalicular bile vs the ductule bile
A
2
Q
contrast the organic vs inorganic components of bile
A
- organic:
- bile acid (cholic acid)
- phosphlipid (lecithin)
- cholesterol
- inorganic:
- Na+
- HCO3-
- Cl-
3
Q
contrast primary vs secondary bile acids
A
4
Q
describe the conjugation of bile acids to bile salts
A
5
Q
the formation of bile by hepatocytes is an _____ process
A
the formation of bile by hepatocytes is an active process
Energy dependent secretion of inorganic and organic solutes into the canalicular lumen; water follows passively
6
Q
describe the factors that regulate the formation of bile
A
7
Q
describe the differences between gallbladder bile and hepatic bile
A
- bile volume secreted > capacity of gall bladder
- gall bladder concentrates bile
- epithelial cells of gall bladder absorb water passively and secondary active transport
- organic constituents become more concentrated (20x)
- gall bladder epithelial cells secrete mucins and H+ protects gallbladder lining and neutralizes bile
8
Q
describe gallbladder function during digestion and during interdigestive phases
A
- interdigestive phase = relaxed gallbladder (+ contracted Sphincter of Oddi)
- digestive phase = contractions of gallbladder (+ relaxation of Sphincter of OddI)
- mediators of contraction: 20% ACh and 80% CCK
