Structure & Function

Question 1

Describe the primary structure

Answer 1

sequence of amino acids

Question 2

Polypeptides can rotate around the angles of what?

Answer 2

alpha carbon and amino/carboxyl group

Question 3

Describe secondary structure

Answer 3

Hydrogen bonded 3D arrangement of amino chain

Question 4

Give an example of a secondary structure

Answer 4

alpha helix, beta sheet, triple helix

Question 5

Describe tertiary structure

Answer 5

3D structure of entire polypeptide

Question 6

What are the two possible directions a beta sheet can travel?

Answer 6

parallel or antiparallel

Question 7

Whats important about collagen triple helix?

Answer 7

Component of bone and connective tissue. Most abundant protein in vertebrates.

Question 8

Name the two proteins associated with tertiary structure

Answer 8

Fibrous & Globular

Question 9

What shape are the fibrous and globular proteins?

Answer 9

Fibrous - single axis. Globular - sphere

Question 10

What force stabilises the tertiary structure?

Answer 10

Covalent Disulphide bonds

Question 11

An amino acid with a hydrophobic side chain would cluster where?

Answer 11

Centre of a globular protein

Question 12

Give an example of a singe nucleotide exchange disease.

Answer 12

Sickle cell anaemia

Question 13

Name a disease down to wrong folding of polypeptide

Answer 13

Parkinsons/Alzheimers

Question 14

What do you know about tropocollagen?

Answer 14

X-Y-Gly where x is an amino acid and y is proline or hyroxyproline. Inter chain hydrogen bonds

Question 15

Describe the quaternary structure

Answer 15

spacial arrangement of polypeptide chains in protein with multiple subunits