Immunology 3 Flashcards
1
Q
Production of pro-inflammatory mediators has what affect?
A
local
2
Q
What is the partner receptor to ICAM and VCAM
A
integrins
3
Q
What is diapedesis?
A
when neutrophils squeeze between endothelial cells
4
Q
What are neutrophils attracted by?
A
chemokine produced by mast cells and macrophages
5
Q
What do neutrophils release into extracellular environment?
A
NETs
6
Q
What do NETs do?
A
prevents pathogen spreading
7
Q
What are the 2 late immune responses?
A
neutrophils and complement
8
Q
What is C3 split into?
A
C3a+C3b
9
Q
Name some downstream events
A
pathogen killing or pathogen opsonisation
10
Q
What is opsonisation?
A
coating of pathogens of opsonins to facilitate phagocytosis
11
Q
C3a and C5a are known as what and do what?
A
known as anaphylatoxins and promote inflammation
