Chronic Inflammation 1

Question 1

Lymphocyte

Answer 1

Immune response that releases antibodies (B cells), cytotoxic granules (cytotoxic T cells) or by signalling to other cells of the immune system (helper T cells).

Question 2

Plasma Cells

Answer 2

Differentiated B cells that produce antibodies specific to the antigen

Question 3

Macrophages

Answer 3

Type of phagocyte, which detects, engulfs and destroys pathogens.
They’re produced through the differentiation of monocytes

Question 4

Fibroblasts

Answer 4

Makes and assembles structural proteins - ECM and collagen

Question 5

Causes of chronic inflammation.

Answer 5

Acute inflam. unable to remove debris or large volume of damage.

Primary lesions - no acute phase

Question 6

Healing and repair process by granulation tissue

Answer 6

1. Capillaries grow into inflammatory mass
2. Plasma proteins and macrophages move from capillaries into damaged tissue
3. Fibroblasts produces collagen - repair framework
4. Collagen replaces inflammatory exudate

Question 7

Adverse effects of tissue scarring

Answer 7

Fibrous scar tissue

Can restrict movement - scarred lung after interstitial pneumonia - harder to breathe

Question 8

Effects of chronic inflammation

Answer 8

Granulation tissue repairs and leads to fibrosis and formation of a scar