Antipsychotics and Parkinson treatments Flashcards
1
Q
FGAs - high potency
A
- Haloperidol
- Trifluoperazine
- Fluphenazine
- Treat only positive symptoms, extrapyramidal SEs
2
Q
FGAs - low potency
A
- Chlorpromazine
- Thioridazine
- Treat only positive symptoms, H & mACh side effects, dangerous side effects: NMS, torsade de pointes
3
Q
SGAs
A
- Quetiapine
- Olanzapine
- Risperidone
- Aripiprazole
- Ziprasidone
- Clozapine
- Treat pos + neg symptoms (inh D2 & 5HT2A), special side effects: weight gain, dyslipidemia, hyperglycemia
4
Q
Parkinson medication
A
- Levodopa w/carbidopa, benserazide or a COMT inhibitor
- Trihexyphenidyl (antimuscarinic)
- Benztropine (antimuscarinic)
- Selegiline (MAO-B inhibitor)
- Ropinirole (D2 agonist)
- Pramipexole (D3 agonist)
- Amantidine
5
Q
COMT inhibitors
A
- Tolcapone (both peripheral + central inh, hepatotoxic)
- Entacapone
- Opicapone
6
Q
D2 agonists - ergot derivatives
A
- Bromocryptine
- Cabergoline
7
Q
D2 agonists - non-ergot derivatives
A
- Pramipexole (oral)
- Ropinirole (oral)
- Rotigotine (patch)
- Apomorphine (injection)
8
Q
Centrally acting anticholinergic drugs for Parkinson
A
mAChR antagonists
- Procyclidine
- Trihexyphenidyl
- Dexethimide
- Benztropine
- Biperiden
- Orphenadrine
- Metiexene
- Mainly for drug-induced Parkinsonism, SE: atropine-like
9
Q
MAO-B inhibitors for Parkinsons
A
- Selegiline
- Rasagiline
- Safinamide
10
Q
Treatment alzheimers
A
ACh-esterase inhibitors - Rivastigmine - Donepezil - Galantamine NMDA antagonist - Memantine
11
Q
Huntington treatment
A
- GABAergic drugs
- Tetrabenzine (monoamine depletor)
- Antipsychotics
12
Q
Vascular demetia treatment
A
Similar to alzheimers Gingko biloba Nootropic agents: - Piracetam - Vinpocetine - Nicergoline
13
Q
Wilson’s disease treatment
A
- D-penicillamine
- Trientine (chelators)
- Zn
14
Q
ALS “treatment”
A
Riluzole - increase survival w/2 months
15
Q
FGAs - dimethylamines (3)
A
1) Chlorpromazine (inject)
2) Levomepromazine (H1 inh)
3) Promethazine