lecture 3 tubular structure and function Flashcards
what are the two ways fluid can leave the tubules
paracellular
transcellular
what is paracellular
between the PCT cells
what is transcellular
though the PCT cells
primary active transprort pump
Na-K
how does the Na-K pump work
ATP is used to drive Na ions into interstitial space
where does the Na-K pump work
basolateral membrane
what does th PCT allow
2/3 of things filtered out
what substance should be completely reabsorbed
glucose
how is glucose drawn into cell (in early PCT)
sodium potassium pump creates a sodium gradient
sodium moves into cell through SGLT2 co transported with glucose
how does glucose get from cell into interstitial space (in early PCT)
GLUT2 transported on basolateral surface
how is the late PCT different for moving glucose
SGLT1
GLUT1
how is SGLT1 diifferent
higher affinity
blood glucose conc
there is a limit
facilitated transport may stop if glucose too high in blood
if glucose is super high it gets excreted into filtrate
when would you find glucosuria
diabetes
are amino acids filtered at the glomerulus
yes
