Musculoskeletal pharm

Question 1

Colchicine

Answer 1

Acute gout drug

Binds and stabilizes tubulin to inhibit
microtubule polymerization, impairing
neutrophil chemotaxis and degranulation. Acute and prophylactic value. GI side effects.

Question 2

Glucocorticoids

Answer 2

• Blocks phospholipase A2 which converts membrane phospholipids into arachidonic acid
• Also blocks NF kappaB
• Treats acute gout attack

Adverse effects

• can cause myopathy
• inhibits peripheral conversion of T4 to T3
• acne
• alopecia
• Cushingoid appearance
• hypertrichosis
• hypertension
• premature atherosclerosis
• gastritis
• peptic ulcer disease
• hypokalemia
• ammenorrhea/infertility
• osteoporosis
• insomnia
• diabetes mellitus.