Aspirin

Question 1

Aspirin Class

Answer 1

Non-steroidal anti-

inflammaotry drugs

Question 2

Aspirin Actions

Answer 2

Reduces inflammation
Analgesic for
inflammaotry pain
Is antipyretic

Question 3

Aspirin Mechanisms of Action

Answer 3

Irreversible acetylation of
cyclo-oxygenases
Weakly COX 1 selective

Question 4

Aspirin Clinical use

Answer 4

Antithrombotic in
myocardial infarction
Other NSAIDs are
preffered for anti-
inflammaotry actiona dn
analgesua in musculo-
skeletal conditions

Question 5

Aspirin Adverse effects

Answer 5

GI disturbances
Gastric bleeding
Salicyclism
Allergic reactions
Renal toxicity

Question 6

What effects does Asprin have?

Answer 6

analgesic, antipyretic, and anti-inflammatory effect

Question 7

how is Aspirn able to have analgesic, antipyretic, and anti-inflammatory effects

Answer 7

due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite

Question 8

what does Acetylsalicylic acid do

Answer 8

directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid

Question 9

what is a result of Acetylsalicylic acid’s analgesic and anti-inflammatory mechanisms

Answer 9

antirheumatic actions

Question 10

what happens during the . Irreversible inhibition of COX

Answer 10

prevention the formation of the aggregating agent thromboxane A2 in platelets. Platelets cannot produce more COX enzyme

Question 11

how long does the effects of aspirin percist?

Answer 11

for the life of the exposed platelets (7-10 days).