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Endocrine > thyroid drugs > Flashcards

thyroid drugs Flashcards

1. Describe the synthesis and release of thyroid hormone and describe the relationship between T3 and T4 in terms of production, potency, protein binding, and metabolism. 2. Describe the rationale for the approaches used in the pharmacological treatment of hyperthyroidism. 3. List the prototype oral drugs used to treat hyperthyroidism, describe their mechanism of action and list their major side effects and clinical uses. 4. Explain the source and function of circulating iodide and its dual a

1
Q

Levothyroxine

A

Thyroid replacement

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2
Q

liothyronine

A

Thyroid replacement

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3
Q

liotrix

A

Thyroid replacement

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4
Q

thyroglobulin

A

Thyroid replacement

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5
Q

DOC for hypothyroidism

A

levothyroxine

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6
Q

levothyroxine mimics

A

T4

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7
Q

liothyronine

A

T3

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8
Q

issue with generic levothyroxines

A

different generics are absorbed at different rates

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9
Q

rapid onset, short DOA Thyroid replacement

A

liothyroxine

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10
Q

can cause myxedema coma

A

liothyroxine

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11
Q

can be cardiotoxic

A

liothyroxine

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12
Q

mixture of T3 and T4

A

liotrix

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13
Q

purified hog thyroid extract

A

thyroglobulin

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14
Q

instable, variable product that can cause antigenic issues

A

thyroglobulin

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15
Q

most potent Thyroid replacement

A

liothyroxine

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16
Q

general SE of Thyroid replacement drugs

A

hyperthyroidism

CV side effects

17
Q

population needed to be cautious with with Thyroid replacement drugs

A

elderly, esp with CV disease

18
Q

MOA of Propylthiouracil

A

interferes with deionization of T4 into Active T3

19
Q

organification

A

creating I2 out of ionized Iodine

20
Q

coupling

A

DIT to T4 step

21
Q

hormone created by the thyroid

A

T4

22
Q

active thyroid hormone

A

T3

23
Q

MOA of thioamides in general

A

prevents synthesis of active T3 by blocking organification, coupling or deiodination

24
Q

SE of thioamides in general

A

skin rash, headache, nausea, leukopenia, agranulocytosis

25
Q

MOA of iodides

A

decreases the size and vascularity of the hyperplastic thyroid gland. blocks organification and release of T4

26
Q

drug to use before thyroid removal

A

iodide

27
Q

contraindications to iodides

A

use before I 131

28
Q

increased iodine stores will

A

delay thionamide onset

29
Q

withdrawal of iodide therapy can

A

precipitate thyrotixicosis

30
Q

iodide drugs (3)

A

lugol’s solution, KI Sodium ipodate

31
Q

used to asess thyroid responsiviness

A

Radioactive iodide

32
Q

destroys iodide tissues

A

I 131

33
Q

suppresses clinical sx of hyperthyroidism

A

propranolol

34
Q

use of propranolol in thyroid dx

A

shortterm until definitive therapy

35
Q

steps of Thyroid hormone biosynthesis

A

trapping, organification, incorporation, coupling, proteolysis and release

36
Q

intermediate thyroid hormone products

A 
thyroglobiln
MIT
DIT
T4
T3
37
Q

T4 converted to T3 where?

A

bloodstream

38
Q

amino acid used in thyroid hormone sythesis

A

thyrosine

39
Q

effect of THs and catcholamines

A

potientate each other

Endocrine (13 decks)

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