Clinical thyroid disease

Question 1

List 4 diseases of the thyroid

Answer 1

• Hyperthyroidism
• Hypothyroidism
• Goitre
• Thyroid Cancer

Question 2

List the symptoms of hyperthyroidism

Answer 2

o	Weight Loss
o	Anxiety/Irritability
o	Heat Intolerance
o	Bowel frequency
o	Light periods
o	Sweaty palms
o	Palpitations
o	Hyper-reflexia/Tremors
o	Goitre
o	Thyroid eye symptoms/signs

Question 3

List the symptoms of hypothyroidism

Answer 3

o	Weight Gain
o	Lethargy
o	Feeling cold
o	Constipation
o	Heavy periods
o	Dry Skin/Hair
o	Bradycardia
o	Slow reflexes
o	Goitre
o	Severe – puffy face, large tongue, hoarseness, coma

Question 4

Describe briefly the biochemical findings of primary hypothyroidism

Answer 4

• Raised TSH, Low FT4 & FT3

Question 5

Describe briefly the biochemical findings of secondary hypothyroidism

Answer 5

• Secondary (Pituitary):

* Low TSH, Low FT4 & FT3

Question 6

Describe briefly the biochemical findings of subclinical hypothyroidism

Answer 6

• Subclinical (Compensated):

* Raised TSH: Normal FT4 & FT3

Question 7

What % of women have hypothyroidism?

Answer 7

1.9% of women

Question 8

What % of men have hypothyroidism?

Answer 8

O.1% of men

Question 9

What % of the population have subclinical hypothyroidism?

Answer 9

Subclinical hypothyroidism - 5% of population

Question 10

What % of the women over 60yo have subclinical hypothyroidism?

Answer 10

10% of women over the age of 60

Question 11

Describe the incidence of congenital hypothyroidism at birth

Answer 11

1 in 3500 births