Sketchy Pharm: Protease Inhibitors Flashcards
Just like the NNRTIs, the protease inhibitors do not require a _______________.
phosphorylation prior to activation
Think of the knight running off in the distance with the unneeded P scroll.
The protease inhibitors all end in the __________ suffix.
-navir (so Sketchy centered this scene around Guinevere)
Which gene encodes the HIV protease?
The pol gene (like Paul the village blacksmith making swords)
HIV proteases are necessary for the ___________ of HIV.
maturation
(To symbolize this, Sketchy has a young, immature boy trying to pull the sword out of the stone but woefully unable to do so.)
How does HIV develop resistance to protease inhibitors?
It can modify its POL gene which allows it to evade the protease inhibitors.
(Think of the modified swords that can slide out of the rock more easily.)
A common long-term side effect of the HIV protease inhibitors is ____________.
hyperglycemia and dyslipidemia (just like Guinevere raising the jar of candy and the stick of butter above the rambunctious little kids)
Just like stavudine and zidovudine, the HIV protease inhibitors can cause ______________.
lipodystrophy with central redistribution of fat
Think of the weird fat horse with skinny legs behind Guinevere.
Nephrolithiasis can start within days of starting ____________.
indinavir; as such, hydration must be maintained
(Think of the INDIgo princess tossing rocks into the kidney-shaped fountain; also, there is a kid drinking from the fountain to symbolize hydration.)
____________ is a potent inhibitor of CYP-450.
Ritonavir (like the kids high-fiving –”right on!” –behind the carriage with the broken down wheel and the CYP license plate)
Ritonavir is contraindicated in patients taking ______________.
rifampin (like the rifleman speeding alongside the princesses and shooting at them)
