Infectious Particle Mastering Flashcards
In which stage does formation of mature viruses occur?
assembly
The host DNA is usually degraded during which stage?
biosynthesis
What would be the fate of a lytic bacteriophage if the host cell died prior to the assembly stage?
the virus would not be able to infect new hosts
Lysogenic viral DNA integrating into the host genome is referred to as
prophage
Which of the following events might trigger induction of a temperate bacteriophage?
exposure to UV light
How is the lytic cycle different from the lysogenic cycle with respect to the infected host cell?
the host cell dies during the lytic cycle
From which phrase is the term “prions” derived?
Proteinaceous infectious particles
In what year did Stanley Prusiner discover prions?
1982
Which disease did Stanley Prusiner first identify as being caused by prions?
scrapie
How are prions different from other infectious agents?
they lack nucleic acid
The normal function of the PrP protein in mammals is believed to be:
assisting in normal synaptic development and function.
How do normal prion proteins (PrP) differ from the infectious prion proteins?
Normal PrP have alpha-helices; infectious PrP have beta-pleated sheets.
How does the number of infectious prions increase?
Prions transform normal proteins into the misfolded beta-pleated sheet configuration; therefore, prions multiply by conversion.
Why are the beta-pleated multimers of PrP potentially pathogenic?
The multimers are more stable and resistant to protease.
what are viroids
Viroids are short pieces of naked RNA.
infectious piece of RNA without a capsid.
