Lectures 7 & 8

Question 1

Permeability

Answer 1

Ease by which ions pass through channel

Defined in terms of reference ion

Question 2

A channel is selective for an ion when

Answer 2

It is more permeable to the ion of interest

Question 3

All iGlus are permeant to

Answer 3

Monovalent cations

Na+, K+

Question 4

Which iGlus are also permeable to divalent cation Ca2+

Answer 4

NMPARs
Some KARs
GluA2 lacking AMPARs

Question 5

AMPAR conductance

Answer 5

Very fast

Rapid decay

Question 6

NMDARs open

Answer 6

Slowly and close slowly

Question 7

Potency is ___________ correlates with ________

Answer 7

Positively

Binding affinity

Question 8

Rate of deactivation is __________ correlated with _________

Answer 8

Negatively

Potency

Question 9

External Mg2+ is an

Answer 9

Open NMDAR channel blocker

Aka uncompetitive blocker

Question 10

Mementine is a

Answer 10

Uncompetitive NMDAR blocker used to treat moderate to severe AD

Question 11

Ketamine is a

Answer 11

Uncompetitive blocker of NMDAR

Question 12

Two examples of non competitive antagonists of NMDAR

Answer 12

Zn2+

Ifenprodil

Question 13

Non competitive AMPAR

Answer 13

Perampanel

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