Respiratory Flashcards
1
Q
Number drugs in development since completion of human genome project
Approvals
A
Up 62%
Down 25%- phase 2 failures
2
Q
Amiloride
A
ENac blocker
Diuretic
Potassium sparing
3
Q
Benefits of reverse pharmacology (3)
A
Historical success
Likely to find drug-like compounds
Insight into target biology
4
Q
Drawback of reverse pharmacology
A
Will target be relevant to disease
5
Q
FSK
A
Toxin Activation of AC Increase in cAMP CFTR phosphorylation Channel opens
6
Q
Genistein
A
Enhances CFTR activity has little effect on current at 37 but increases current at 26
Lower temperature seems to facilitate processing of F508
Still only 10% of WT
7
Q
Frequency of F508
A
More than 90% patients have at least one copy
49% are homozygous
